Details of the Drug Pharmacogenomic Perturbation Atlas

ML218 Drug Info

ML-218; ML 218

Cross-matching ID

PubChem CID

45115620

ChEBI ID

CHEMBL1731994

TTD Drug ID

D09PWJ

General Information of Drug (ID: DM3D21X)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Gap junction	2.05	0.00e+0	72/88 (81.82%)	SRC;PDGFD;PRKCB;...
Graft-versus-host disease	-1.78	2.88e-2	32/42 (76.19%)	HLA-DOA;HLA-A;IL1B;...
Rheumatoid arthritis	-1.80	2.66e-2	78/93 (83.87%)	MMP1;CD86;HLA-DPB1;...
Phagosome	-1.82	2.76e-2	118/152 (77.63%)	HLA-DRA;FCGR2B;ATP6V0B;...
Antigen processing and presentation	-1.86	1.86e-2	60/78 (76.92%)	CD74;TAP2;HLA-E;...
Oxidative phosphorylation	-1.87	2.13e-2	93/133 (69.92%)	NDUFS6;COX7A2L;ATP6V0A4;...
Type I diabetes mellitus	-1.89	2.13e-2	38/43 (88.37%)	FASLG;IL2;CD28;...
Collecting duct acid secretion	-2.06	0.00e+0	22/27 (81.48%)	ATP6V0A4;SLC4A1;TCIRG1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H, 24H