Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3HRQI)

Drug Name
BINOSPIRONE MESYLATE Drug Info
Synonyms
Binospirone mesylate < Rec INNM; MDL-73005EF; Rac-N-[2-[(1,4-Benzodioxan-2-ylmethyl)amino]ethyl]-1,1-cyclopentanediazetimide methanesulfonate; Rac-N-[4-(1,4-Benzodioxan-2-ylmethylamino)ethyl]-3,3-tetramethyleneglutarimide methanesulfonate; Rac-8-[2-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methylamino]ethyl]-8-azaspiro[4.5]decane-7,9-dione methanesulfonate
Cross-matching ID
PubChem CID
71346
CAS Number
CAS 124756-23-6
TTD Drug ID
D05AAM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.28 0.00e+0 113/158 (71.52%) RPS4Y1;MRPL20;MRPS15;...
Ribosome biogenesis in eukaryotes 1.98 3.34e-3 52/108 (48.15%) NVL;IMP3;NXT2;...
Pyrimidine metabolism 1.80 3.34e-2 40/56 (71.43%) ENPP1;TYMS;CTPS1;...
Rap1 signaling pathway -1.74 4.96e-2 184/210 (87.62%) FPR1;CTNNB1;HGF;...
Kaposi sarcoma-associated herpesvirus infection -1.87 1.91e-2 172/193 (89.12%) STAT2;TRADD;STAT3;...
Rheumatoid arthritis -1.87 2.19e-2 78/93 (83.87%) CSF1;VEGFA;FLT1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.91 1.70e-2 62/70 (88.57%) CXCR1;MAPK14;NFKBIA;...
NOD-like receptor signaling pathway -1.97 7.65e-3 145/181 (80.11%) STAT2;VDAC1;MFN1;...
Mineral absorption -1.98 6.38e-3 48/60 (80%) SLC5A1;SLC34A1;ATP2B1;...
TNF signaling pathway -2.03 4.25e-3 103/112 (91.96%) IRF1;MAPK14;NFKBIA;...
NF-kappa B signaling pathway -2.15 6.38e-3 90/104 (86.54%) ZAP70;CD40LG;TRADD;...
IL-17 signaling pathway -2.26 0.00e+0 84/94 (89.36%) MAPK14;NFKBIA;PTGS2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H