Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3INX7)

Drug Name
EPZ015666 Drug Info
Synonyms EPZ-015666; EPZ 015666
Cross-matching ID
PubChem CID
90241673
ChEBI ID
CHEMBL4060831
TTD Drug ID
D05XQD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.45 0.00e+0 113/158 (71.52%) RPL10;RPL26;RPL14;...
Spliceosome 2.31 0.00e+0 101/150 (67.33%) SNRPB;PRPF4;SNRPB2;...
Ribosome biogenesis in eukaryotes 2.21 0.00e+0 52/108 (48.15%) FBL;HEATR1;NHP2;...
Cardiac muscle contraction 2.02 0.00e+0 64/87 (73.56%) TPM4;TNNC1;MYL2;...
RNA transport 1.92 1.85e-3 128/186 (68.82%) EIF2S3;RPP14;EIF5B;...
Dilated cardiomyopathy 1.90 3.08e-3 86/96 (89.58%) TPM4;TNNC1;MYL2;...
Starch and sucrose metabolism 1.85 9.25e-3 25/36 (69.44%) HK2;ENPP1;GYG1;...
DNA replication 1.81 1.73e-2 34/36 (94.44%) PCNA;POLE3;MCM6;...
Nicotine addiction 1.78 2.36e-2 32/40 (80%) GABRE;SLC17A7;GABRA1;...
Diabetic cardiomyopathy 1.75 2.59e-2 162/203 (79.8%) MMP9;NDUFAB1;VDAC1;...
Oxidative phosphorylation 1.73 2.78e-2 93/133 (69.92%) NDUFAB1;ATP5MG;ATP5F1C;...
Nitrogen metabolism 1.72 3.08e-2 16/17 (94.12%) CA2;GLUL;CA4;...
Complement and coagulation cascades -1.94 1.60e-2 76/85 (89.41%) MBL2;F11;PROS1;...
Cysteine and methionine metabolism -2.00 0.00e+0 43/50 (86%) KYAT3;MPST;GSS;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H