Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3L52Q)

Drug Name
Chlorcyclizine Drug Info
Synonyms
1-(4-Chlorobenzhydryl)-4-methylpiperazine; Alergicide; Chlorcycline; Chlorcyclizine [INN:BAN]; Chlorcyclizinum; Chlorcyclizinum [INN-Latin]; Chlorocycline; Chlorocyclizine; Clorciclizina; Clorciclizina [DCIT]; Clorciclizinio [INN-Spanish]; Compound 47-282; Di-Paralene; Di-paralen; Diparalene; HSDB 3217; Histachlorazene; Histantin; Histantine; N-Methyl-N'-(4-chlorobenzhydryl)piperazine; NSC 25246; Perazyl; Piparalene; Trihistan; chlorcyclizine
Therapeutic ClassAntihistamines
Cross-matching ID
PubChem CID
2710
ChEBI ID
CHEMBL22150
CAS Number
CAS 82-93-9
VARIDT Drug ID
DR01215

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Neutrophil extracellular trap formation -1.74 3.90e-2 101/189 (53.44%) PIK3R1;VDAC1;CASP4;...
HIF-1 signaling pathway -1.78 3.96e-2 105/109 (96.33%) IFNG;PIK3R1;SLC2A1;...
Legionellosis -1.89 1.19e-2 51/57 (89.47%) NFKB1;MYD88;RELA;...
Regulation of lipolysis in adipocytes -1.96 8.91e-3 52/55 (94.55%) PIK3CB;AKT1;ADORA1;...
NF-kappa B signaling pathway -1.99 7.92e-3 90/104 (86.54%) TRIM25;LYN;TRAF6;...
Malaria -1.99 1.19e-2 44/50 (88%) MYD88;LRP1;SELE;...
Steroid biosynthesis -2.11 0.00e+0 19/20 (95%) HSD17B7;FDFT1;NSDHL;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H