Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3NMT6)

Drug Name
Articaine Drug Info
Synonyms
Articaine; Carticaine; 23964-58-1; Articaine [INN:BAN]; Articainum [INN-Latin]; Articaina [INN-Spanish]; Hoe-045; Ultracain; HOE 045; methyl 4-methyl-3-[(N-propylalanyl)amino]thiophene-2-carboxylate; methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate; Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat); Q-200652; Articainum; Articaina; 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid, methyl ester; 2-Thiophenecarboxylicacid, 4-methyl-3-[[1-oxo-2-(propylamino)propy
Cross-matching ID
PubChem CID
32170
ChEBI ID
CHEMBL1093
CAS Number
CAS 23964-58-1
TTD Drug ID
D0I5HV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.32 0.00e+0 34/36 (94.44%) RFC5;PCNA;POLE3;...
Proteasome 2.12 0.00e+0 44/46 (95.65%) PSMB2;PSMB10;PSMC3;...
Oocyte meiosis 1.83 2.23e-2 90/129 (69.77%) CCNB2;CDC20;IGF1;...
Nucleotide excision repair 1.82 1.67e-2 40/47 (85.11%) RFC5;PCNA;POLE3;...
Cell cycle 1.80 1.74e-2 110/124 (88.71%) CCNB2;CDC20;PCNA;...
Mineral absorption 1.79 1.78e-2 48/60 (80%) HEPH;MT1E;SLC26A3;...
Mismatch repair 1.78 1.62e-2 22/23 (95.65%) RFC5;PCNA;EXO1;...
Progesterone-mediated oocyte maturation 1.68 4.18e-2 75/100 (75%) CCNB2;IGF1;MAD2L1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H