Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3NXRU)

• Drug Name: Timolol Drug Info
• Synonyms: Aquanil; Betim; Betimol; Blocadren; Istalol; Optimol; Proflax; TIM; Temserin; Tenopt; Timacar; Timololum; Timopic; Timoptol; Timolol GFS; Timolol [USAN]; Timoptic OcuDose; Apo-Timol; Apo-Timop; Betimol (TN); Blocadren (TN); Istalol (TN); MK-950; Novo-Timol; Nu-Timolol; Phoxal-timolol; Tim-AK; Timolol (INN); Timolol (TN); Timololum [INN-Latin]; Timoptic (TN); Timoptic-XE; Apo-Timol (TN); Apo-Timop (TN); Gen-Timolol (TN); L-714,465; Nu-Timolol (TN); PMS-Timolol (TN); Phoxal-timolol (TN); Tim-AK (TN); Timoptic OcuDose. (TN); Timoptic-XE (TN); S(-)-Timolol maleate; Timolol Maleate, (1:1) Salt; S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole; (-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole; (2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; (2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; (S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol; (S)-timolol
• Therapeutic Class: Antiarrhythmic Agents
• Cross-matching ID:
  PubChem CID: 33624
  ChEBI ID: CHEMBL499
  CAS Number: CAS 26839-75-8
  TTD Drug ID: D05UVD
  VARIDT Drug ID: DR00900
  INTEDE Drug ID: DR1595
  ACDINA Drug ID: D00677

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Primary immunodeficiency	1.98	0.00e+0	33/38 (86.84%)	CD8A;CD3D;TAP1;...
Longevity regulating pathway	-1.70	3.72e-2	90/151 (59.6%)	FOXA2;PRKAG2;HSPA2;...
Ribosome	-1.71	3.39e-2	113/158 (71.52%)	RPL11;RPS21;FAU;...
Ferroptosis	-1.74	2.50e-2	36/41 (87.8%)	ALOX15;FTL;NCOA4;...
Diabetic cardiomyopathy	-1.74	2.75e-2	162/203 (79.8%)	AGTR1;RAC2;TGFBR1;...
Sphingolipid metabolism	-1.74	2.81e-2	32/49 (65.31%)	PLPP3;CERS4;KDSR;...
Legionellosis	-1.84	9.63e-3	51/57 (89.47%)	CYCS;CASP3;IL6;...
Glyoxylate and dicarboxylate metabolism	-1.85	1.10e-2	23/30 (76.67%)	CAT;DLD;MDH2;...
Non-alcoholic fatty liver disease	-1.85	1.10e-2	126/155 (81.29%)	BID;NDUFA3;INSR;...
Synthesis and degradation of ketone bodies	-1.87	1.10e-2	9/10 (90%)	ACAT1;HMGCS2;HMGCS1
Valine, leucine and isoleucine degradation	-1.91	1.10e-2	42/48 (87.5%)	ALDH7A1;ECHS1;HMGCL;...
Oxidative phosphorylation	-1.95	1.10e-2	93/133 (69.92%)	ATP6V1B1;NDUFA3;LHPP;...
Steroid biosynthesis	-2.10	0.00e+0	19/20 (95%)	CYP2R1;SOAT1;LSS;...
Steroid hormone biosynthesis	-2.42	0.00e+0	43/61 (70.49%)	UGT2B17;AKR1C2;HSD3B1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM - 10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼