General Information of Drug (ID: DM3OP41)

Drug Name
LXR 623 Drug Info
Synonyms LXR-623
Cross-matching ID
PubChem CID
16734800
ChEBI ID
CHEMBL456237
CAS Number
CAS 875787-07-8
TTD Drug ID
D0R4EN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.41 0.00e+0 48/60 (80%) MT1E;MT1F;MT1X;...
Steroid biosynthesis 2.01 5.36e-3 19/20 (95%) MSMO1;CYP51A1;SQLE;...
Peroxisome 1.91 2.15e-2 72/82 (87.8%) PRDX1;AMACR;ACOX2;...
Propanoate metabolism 1.86 2.15e-2 30/34 (88.24%) ABAT;ACAT2;DLD;...
Renin secretion 1.86 1.72e-2 61/69 (88.41%) AQP1;GNAI1;GNAS;...
Terpenoid backbone biosynthesis 1.86 1.61e-2 18/22 (81.82%) HMGCS2;ACAT2;HMGCS1;...
Tryptophan metabolism 1.75 3.83e-2 35/42 (83.33%) AOC1;ALDH8A1;ACAT2;...
Proximal tubule bicarbonate reclamation 1.74 3.89e-2 21/23 (91.3%) AQP1;PCK1;GLUD1;...
Valine, leucine and isoleucine degradation 1.73 3.93e-2 42/48 (87.5%) HMGCS2;ABAT;ACAT2;...
Synthesis and degradation of ketone bodies 1.73 3.65e-2 9/10 (90%) HMGCS2;ACAT2;HMGCS1;...
Citrate cycle (TCA cycle) 1.70 4.49e-2 30/30 (100%) PCK1;DLST;DLD;...
Steroid hormone biosynthesis 1.70 4.56e-2 43/61 (70.49%) AKR1C3;CYP1B1;HSD17B7;...
Glycine, serine and threonine metabolism 1.69 4.54e-2 31/40 (77.5%) PGAM1;GATM;DLD;...
Metabolism of xenobiotics by cytochrome P450 1.67 4.75e-2 49/77 (63.64%) CYP1B1;GSTT2;GSTP1;...
Ovarian steroidogenesis 1.67 4.72e-2 41/51 (80.39%) GNAS;AKR1C3;CYP1B1;...
Cell adhesion molecules -1.68 3.15e-2 118/148 (79.73%) CADM1;HLA-DOB;HLA-DOA;...
Type I diabetes mellitus -1.71 2.90e-2 38/43 (88.37%) HLA-DRA;HLA-DRB1;GZMB;...
Intestinal immune network for IgA production -1.76 1.46e-2 38/48 (79.17%) TGFB1;ITGA4;HLA-DRA;...
Leishmaniasis -1.78 1.09e-2 67/77 (87.01%) MARCKSL1;JAK2;C3;...
Asthma -1.90 1.84e-3 25/31 (80.65%) HLA-DRA;HLA-DRB1;HLA-DPA1;...
Systemic lupus erythematosus -1.94 1.02e-3 45/135 (33.33%) CD80;HLA-DOB;HLA-DOA;...
Th1 and Th2 cell differentiation -1.95 1.15e-3 80/92 (86.96%) PLCG1;RBPJ;HLA-DOB;...
Graft-versus-host disease -1.95 1.31e-3 32/42 (76.19%) KLRD1;HLA-DRA;HLA-DRB1;...
Hematopoietic cell lineage -2.05 1.53e-3 90/99 (90.91%) HLA-DMB;ITGA2;CD4;...
Th17 cell differentiation -2.06 0.00e+0 95/107 (88.79%) PLCG1;IL1R1;HLA-DOB;...
Viral myocarditis -2.08 0.00e+0 53/60 (88.33%) CD80;HLA-DOB;HLA-DOA;...
Allograft rejection -2.10 0.00e+0 32/38 (84.21%) HLA-DRA;HLA-DRB1;GZMB;...
Primary immunodeficiency -2.11 0.00e+0 33/38 (86.84%) RAG2;TAP1;RFXANK;...
Autoimmune thyroid disease -2.34 0.00e+0 46/53 (86.79%) HLA-DRA;HLA-DRB1;GZMB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.03uM - 10uM 24H