General Information of Drug (ID: DM3OWT4)

Drug Name
Tindamax Drug Info
Synonyms Tinidazole (oral), Mission Pharmacal
Cross-matching ID
PubChem CID
5479
ChEBI ID
CHEMBL63627
CAS Number
CAS 148159-84-6
TTD Drug ID
D0O4SE
INTEDE Drug ID
DR1596
ACDINA Drug ID
D00678

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.05 0.00e+0 34/36 (94.44%) DNA2;POLE2;RFC5;...
Drug metabolism 1.97 2.99e-3 78/151 (51.66%) ADH5;GSTA1;CES2;...
Retinol metabolism 1.89 3.99e-3 41/68 (60.29%) ALDH1A3;ADH5;RDH11;...
Fanconi anemia pathway 1.78 3.89e-2 36/54 (66.67%) RMI1;RAD51C;FANCA;...
Glutathione metabolism 1.73 4.66e-2 43/57 (75.44%) GSTA1;GSTP1;GPX3;...
Non-homologous end-joining 1.72 4.48e-2 11/13 (84.62%) FEN1;PRKDC;MRE11;...
Oxidative phosphorylation 1.70 4.01e-2 93/133 (69.92%) NDUFB1;NDUFA3;COX6B1;...
Pantothenate and CoA biosynthesis 1.67 4.71e-2 14/21 (66.67%) DPYD;ALDH3A2;ENPP1;...
Propanoate metabolism -1.68 2.30e-2 30/34 (88.24%) ACAT2;BCKDHA;LDHA;...
Yersinia infection -1.69 2.24e-2 120/137 (87.59%) DOCK1;LCP2;MEFV;...
Chagas disease -1.69 2.31e-2 93/102 (91.18%) GNAO1;PLCB4;FASLG;...
T cell receptor signaling pathway -1.70 2.30e-2 93/104 (89.42%) MAPK1;MAP3K8;DLG1;...
Mineral absorption -1.71 2.13e-2 48/60 (80%) SLC39A4;MT1F;TRPV6;...
MicroRNAs in cancer -1.71 2.21e-2 146/310 (47.1%) MAPK1;CRKL;SOX4;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.71 2.13e-2 79/89 (88.76%) MAPK1;MAPK11;TLR2;...
Non-small cell lung cancer -1.72 2.21e-2 70/72 (97.22%) HGF;FOXO3;CASP9;...
Glyoxylate and dicarboxylate metabolism -1.72 2.19e-2 23/30 (76.67%) CS;ACAT2;GRHPR;...
Malaria -1.73 2.22e-2 44/50 (88%) SELP;TLR2;ICAM1;...
PI3K-Akt signaling pathway -1.74 2.16e-2 317/354 (89.55%) FASLG;CDC37;TNC;...
Shigellosis -1.74 2.27e-2 180/246 (73.17%) CDC42;CSF2;PIK3R4;...
HIF-1 signaling pathway -1.77 1.97e-2 105/109 (96.33%) SLC2A1;NPPA;MAPK1;...
Pancreatic cancer -1.77 2.09e-2 75/76 (98.68%) CASP9;MAPK1;RALB;...
Central carbon metabolism in cancer -1.77 2.04e-2 67/70 (95.71%) SLC2A1;SCO2;TIGAR;...
AGE-RAGE signaling pathway in diabetic complications -1.78 1.80e-2 97/100 (97%) CDC42;SERPINE1;THBD;...
Adherens junction -1.79 1.52e-2 63/71 (88.73%) CSNK2B;PARD3;TGFBR2;...
Endometrial cancer -1.81 1.31e-2 56/58 (96.55%) FOXO3;CASP9;MAPK1;...
Melanoma -1.81 1.42e-2 68/72 (94.44%) FGF9;HGF;FGF1;...
Bladder cancer -1.82 1.16e-2 40/41 (97.56%) MAPK1;DAPK1;FGFR3;...
Aldosterone-regulated sodium reabsorption -1.83 8.51e-3 34/37 (91.89%) NEDD4L;MAPK1;PIK3CA;...
Bacterial invasion of epithelial cells -1.84 7.88e-3 59/77 (76.62%) CDC42;DOCK1;CAV2;...
ErbB signaling pathway -1.85 7.10e-3 79/85 (92.94%) MAPK1;CRKL;JUN;...
Toll-like receptor signaling pathway -1.85 6.08e-3 94/104 (90.38%) STAT1;IFNB1;MAPK1;...
Ferroptosis -1.85 7.10e-3 36/41 (87.8%) ACSL4;PCBP2;CP;...
Platelet activation -1.86 5.68e-3 106/124 (85.48%) ADCY6;GUCY1B1;RAP1B;...
Human cytomegalovirus infection -1.89 7.10e-3 201/225 (89.33%) ARHGEF12;GNA12;IFNB1;...
Chronic myeloid leukemia -1.90 4.73e-3 72/76 (94.74%) MAPK1;GADD45G;CRKL;...
Other glycan degradation -1.91 7.10e-3 13/18 (72.22%) NEU2;HEXA;GLB1;...
FoxO signaling pathway -1.97 0.00e+0 118/131 (90.08%) FASLG;S1PR1;FOXO3;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H