Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3P6V7)

• Drug Name: Furazolidone Drug Info
• Synonyms: Bifuron; Corizium; Coryzium; Diafuron; Enterotoxon; Furall; Furaxon; Furaxone; Furazol; Furazolidine; Furazolidon; Furazolidona; Furazolidonum; Furazolum; Furazon; Furidon; Furovag; Furox; Furoxal; Furoxane; Furoxon; Furoxone; Furozolidine; Giardil; Giarlam; Medaron; Neftin; Nicolen; Nifulidone; Nifuran; Nifurazolidone; Nifurazolidonum; Nitrofurazolidone; Nitrofurazolidonum; Nitrofuroxon; Optazol; Ortazol; Puradin; Roptazol; Sclaventerol; Tikofuran; Topazone; Trichofuron; Tricofuron; Tricoron; Trifurox; Viofuragyn; Fiurox aerosol powder; Furoxone Liquid; Furoxone Swine Mix; NF 180 custom mix ten; F-8900; Furazolidona [INN-Spanish]; Furazolidone [INN:BAN]; Furazolidonum [INN-Latin]; Furox Aerosol Powder (Veterinary); Furoxone (TN); NF-180; Usaf ea-1; Dependal-M (TN); Furazolidone (USP/INN); N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone; N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one; 3-(((5-Nitro-2-furanyl)methylene)amino)-2-oxazolidinone; 3-((5-Nitrofurfurylidene)amino)-2-oxazolidinone; 3-((5-Nitrofurfurylidene)amino)-2-oxazolidone; 3-((5-Nitrofurylidene)amino)-2-oxazolidone; 3-(5'-Nitrofurfuralamino)-2-oxazolidone; 3-(5-Nitrofurfurylideneamino)-2-oxazolidinone; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone; 3-[(5-Nitrofurylidene)amino]-2-oxazolidone; 3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one; 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone; 3-{[(5-Nitro-2-furanyl)methylene]amino}-2-oxazolidinone; 3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one; 3-{[(E)-(5-nitrofuran-2-yl)methylidene]amino}-1,3-oxazolidin-2-one; 5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine
• Therapeutic Class: Antiinfective Agents
• Cross-matching ID:
  PubChem CID: 5323714
  ChEBI ID: CHEMBL5195
  CAS Number: CAS 67-45-8
  TTD Drug ID: D03CUF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Malaria	2.08	0.00e+0	44/50 (88%)	THBS1;IL1B;CXCL8;...
Ribosome	2.06	5.14e-3	113/158 (71.52%)	MRPL15;MRPS12;RPL26L1;...
African trypanosomiasis	1.89	1.37e-2	32/37 (86.49%)	F2RL1;IL1B;VCAM1;...
NF-kappa B signaling pathway	1.85	1.80e-2	90/104 (86.54%)	RELB;IL1B;CXCL8;...
Small cell lung cancer	1.84	1.65e-2	90/92 (97.83%)	MYC;BCL2L1;LAMC2;...
Pyrimidine metabolism	1.74	3.77e-2	40/56 (71.43%)	ENTPD1;DCTPP1;DTYMK;...
p53 signaling pathway	1.73	4.85e-2	63/73 (86.3%)	THBS1;BCL2L1;SFN;...
Chronic myeloid leukemia	1.69	4.89e-2	72/76 (94.74%)	MYC;BCL2L1;GADD45A;...
Ribosome biogenesis in eukaryotes	1.69	4.57e-2	52/108 (48.15%)	NHP2;NXT1;IMP4;...
Protein processing in endoplasmic reticulum	-2.30	0.00e+0	127/171 (74.27%)	LMAN2;DERL2;EIF2AK2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲