Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3PBMR)

• Drug Name: INTERCEPT Drug Info
• Cross-matching ID:
  PubChem CID: 72385
  TTD Drug ID: D05JFA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cysteine and methionine metabolism	1.92	3.53e-2	43/50 (86%)	PHGDH;PSAT1;CBS;...
Ferroptosis	1.89	2.35e-2	36/41 (87.8%)	HMOX1;SLC7A11;SLC39A8;...
Protein processing in endoplasmic reticulum	1.85	2.75e-2	127/171 (74.27%)	DDIT3;HERPUD1;ATF4;...
Oxidative phosphorylation	-1.72	2.42e-2	93/133 (69.92%)	NDUFB1;ATP5F1D;NDUFA6;...
Bacterial invasion of epithelial cells	-1.77	1.29e-2	59/77 (76.62%)	ACTR3B;ACTB;ELMO2;...
Cell cycle	-1.81	1.41e-2	110/124 (88.71%)	HDAC2;CDC20;WEE1;...
Spliceosome	-1.88	2.69e-3	101/150 (67.33%)	NCBP1;PRPF38B;PRPF18;...
Proteasome	-2.06	0.00e+0	44/46 (95.65%)	PSMA5;PSMC4;IFNG;...
DNA replication	-2.09	0.00e+0	34/36 (94.44%)	PRIM1;MCM2;RPA2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼