Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3S5UC)

• Drug Name: ML-3163 Drug Info
• Synonyms: ML 3163; CHEMBL111456; 4-[5-(4-Fluorophenyl)-2-(4-methanesulfinyl-benzylsulfanyl)-3H-imidazol-4-yl]pyridine; SCHEMBL4106398; BDBM50114690; IN1229; 4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfinyl-benzylsulfanyl)-1H-imidazol-4-yl]-pyridine; 4-(2-(4-(methylsulfinyl)benzylthio)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine
• Cross-matching ID:
  PubChem CID: 9845197
  ChEBI ID: CHEMBL111456
  TTD Drug ID: D08DSJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Toll-like receptor signaling pathway	-1.76	3.98e-2	94/104 (90.38%)	TNF;MAP2K2;TLR7;...
Porphyrin and chlorophyll metabolism	-1.83	1.94e-2	23/43 (53.49%)	HMBS;UGT2B15;ALAS2;...
Systemic lupus erythematosus	-1.85	1.54e-2	45/135 (33.33%)	IFNG;C8B;C1R;...
Cytokine-cytokine receptor interaction	-1.85	1.79e-2	246/295 (83.39%)	TNFRSF10B;IL15;BMPR1B;...
Ferroptosis	-1.88	1.19e-2	36/41 (87.8%)	NCOA4;ATG5;STEAP3;...
Staphylococcus aureus infection	-1.89	5.97e-3	72/95 (75.79%)	DEFA5;DEFA6;FPR1;...
Complement and coagulation cascades	-1.91	3.98e-3	76/85 (89.41%)	C8A;BDKRB1;CFHR2;...
Viral protein interaction with cytokine and cytokine re...	-1.95	0.00e+0	84/100 (84%)	TNFRSF10B;CXCL8;TNFRSF1B;...
Protein processing in endoplasmic reticulum	-2.06	0.00e+0	127/171 (74.27%)	RPN1;ERO1B;DNAJB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼