Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3U7SZ)

Drug Name
Romiplostim Drug Info
Cross-matching ID
PubChem CID
5329098
ChEBI ID
CHEMBL276711
CAS Number
CAS 194413-58-6
TTD Drug ID
D01PZD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Dilated cardiomyopathy 1.98 2.42e-2 86/96 (89.58%) GNAS;TNNC1;ADCY3;...
Malaria 1.87 4.84e-2 44/50 (88%) CCL2;ITGB2;THBS2;...
Ascorbate and aldarate metabolism -1.68 3.70e-2 15/30 (50%) RGN;UGT2B17;UGT2B28;...
Oxidative phosphorylation -1.75 1.64e-2 93/133 (69.92%) COX4I1;NDUFA8;ATP4B;...
Parkinson disease -1.76 1.59e-2 176/249 (70.68%) NDUFA7;PSMA5;GNAI2;...
Glycine, serine and threonine metabolism -1.77 1.26e-2 31/40 (77.5%) PSPH;GAMT;DAO;...
Proximal tubule bicarbonate reclamation -1.78 1.23e-2 21/23 (91.3%) ATP1B2;SLC4A4;CA4;...
Mineral absorption -1.78 1.19e-2 48/60 (80%) SLC26A6;STEAP1;MT2A;...
Staphylococcus aureus infection -1.79 1.32e-2 72/95 (75.79%) MASP1;CFB;FPR2;...
Drug metabolism -1.84 1.19e-2 78/151 (51.66%) CDA;FMO1;CYP2E1;...
Prion disease -1.86 1.13e-2 209/273 (76.56%) KLC2;RYR3;PSMB2;...
Bile secretion -1.89 6.61e-3 68/90 (75.56%) ABCG5;SLC4A4;SLC27A5;...
Fatty acid degradation -1.94 7.93e-3 40/43 (93.02%) ACSL6;ACSL1;ECI1;...
Retinol metabolism -1.96 5.95e-3 41/68 (60.29%) ADH5;BCO1;RDH16;...
Porphyrin and chlorophyll metabolism -2.05 0.00e+0 23/43 (53.49%) UGT2B17;UGT2B28;UGT2B4;...
Viral protein interaction with cytokine and cytokine re... -2.07 0.00e+0 84/100 (84%) CXCL8;CCR9;CXCR2;...
Complement and coagulation cascades -2.15 0.00e+0 76/85 (89.41%) F7;PLAT;MASP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H