Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3UGMD)

Drug Name
L-168049 Drug Info
Synonyms Glucagon antagonists (diabetes); SCH-900822; Glucagon antagonists (diabetes), Merck & Co
Cross-matching ID
PubChem CID
5311276
ChEBI ID
CHEMBL351772
CAS Number
CAS 191034-25-0
TTD Drug ID
D0M3AR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.23 0.00e+0 76/85 (89.41%) F3;SERPINB2;SERPINA1;...
Arginine biosynthesis 1.90 3.34e-2 17/22 (77.27%) ASS1;CPS1;ARG1;...
Retinol metabolism 1.89 2.22e-2 41/68 (60.29%) AOX1;UGT2B28;CYP26B1;...
Drug metabolism 1.88 1.91e-2 78/151 (51.66%) AOX1;GSTA1;ALDH3A1;...
Metabolism of xenobiotics by cytochrome P450 1.86 2.10e-2 49/77 (63.64%) GSTA1;CYP1B1;AKR1C1;...
Protein export 1.84 1.75e-2 17/23 (73.91%) OXA1L;SEC62;HSPA5;...
Thyroid hormone synthesis 1.82 1.50e-2 66/75 (88%) GNAS;PLCB3;ALB;...
Ascorbate and aldarate metabolism 1.76 2.38e-2 15/30 (50%) UGT2B28;UGDH;UGT2B4;...
Mineral absorption 1.73 3.71e-2 48/60 (80%) MT1E;MT1F;MT1H;...
PPAR signaling pathway 1.71 4.38e-2 66/74 (89.19%) PCK2;APOA1;FABP4;...
DNA replication -2.05 5.30e-3 34/36 (94.44%) RPA4;POLE;RPA2;...
Spliceosome -2.11 0.00e+0 101/150 (67.33%) SNRPD2;SNRPB;HSPA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H