Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3WRBQ)

Drug Name
Dibenzepin Drug Info
Synonyms
Dibenzepin hydrochloride; Dibenzepine hydrochloride; Dibenzepine HCl; 315-80-0; Dibenzepin HCl; Noveryl; Noveril; Neodalit; Ansiopax; Dibenzepine monohydrochloride; UNII-JLN0273S4Z; Sedatiplex; Ecatril; JLN0273S4Z; Hydrofluoride-1927 wander; HF 1927; Dibenzepin hydrochloride [USAN]; EINECS 206-255-6; Ecatril hydrochloride; NSC 169412; DSSTox_RID_82755; DSSTox_CID_28394; DSSTox_GSID_48421; CAS-315-80-0; NSC169412; NCGC00160395-01; 10-(2-(Dimethylamino)ethyl)-5,10-dihydro-5-methyl-11-H-dibenzo(b,e)(1,4)diazepin-11-one monohydrochlorid
Cross-matching ID
PubChem CID
9419
ChEBI ID
CHEMBL1442422
CAS Number
CAS 4498-32-2
TTD Drug ID
D0P8AY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.91 2.99e-2 34/36 (94.44%) PCNA;POLD2;MCM4;...
Fat digestion and absorption 1.79 4.99e-2 35/43 (81.4%) ACAT1;APOB;FABP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H