Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3WVPJ)

Drug Name
Asacolitin Drug Info
Synonyms
Apriso; Asacol; Asacol HD; 5-Aminosalicylic acid; Benzoic acid, 5-amino-2-hydroxy-; Canasa; Claversal; Fisalamine; Lialda; Lixacol; Mesalamine [USAN]; Mesalazina; Mesalazina [Spanish]; Mesalazine; Mesalazinum; Mesalazinum [Latin]; Mesasal; Pentasa; Rowasa; Salofalk; m-Aminosalicylic acid; mesalamine; p-Aminosalicylsaeure; p-Aminosalicylsaeure [German]; sfRowasa; 2-Hydroxy-5-aminobenzoic acid; 5-ASA; 5-Amino Salicylic Acid; 5-Amino-2-hydroxybenzoic acid; 5-amino-2-hydroxy-benzoic acid; 89-57-6
Cross-matching ID
PubChem CID
4075
ChEBI ID
CHEMBL704
CAS Number
CAS 89-57-6
INTEDE Drug ID
DR1967

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Acute myeloid leukemia 1.91 2.57e-2 66/67 (98.51%) LEF1;BCL2A1;KIT;...
Glycolysis / Gluconeogenesis 1.88 3.08e-2 56/67 (83.58%) LDHB;PFKL;PKM;...
Galactose metabolism 1.88 2.31e-2 26/31 (83.87%) PFKL;AKR1B1;HK2;...
Bladder cancer 1.87 2.26e-2 40/41 (97.56%) MMP1;CXCL8;KRAS;...
Fructose and mannose metabolism 1.82 2.74e-2 30/33 (90.91%) PFKL;AKR1B1;HK2;...
Arginine and proline metabolism 1.81 2.50e-2 39/50 (78%) OAT;AOC1;AMD1;...
Central carbon metabolism in cancer 1.73 3.21e-2 67/70 (95.71%) LDHB;PFKL;PKM;...
Cysteine and methionine metabolism 1.70 4.00e-2 43/50 (86%) LDHB;AMD1;CBS;...
Complement and coagulation cascades -1.94 2.92e-2 76/85 (89.41%) ITGAX;C2;CFHR5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 20uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H