Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3XRJT)

• Drug Name: PRAVADOLINE Drug Info
• Synonyms: Pravadoline; 92623-83-1; (4-Methoxyphenyl)(2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)methanone; UNII-P3JW662TWA; WIN 48098; P3JW662TWA; CHEMBL13178; NCGC00160396-01; DSSTox_RID_81361; DSSTox_CID_26127; DSSTox_GSID_46127; Pravadoline, Pravadoline Maleate; Pravadolina; Pravadolinum; (4-methoxyphenyl)-[2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]methanone; SMR001550504; Pravadoline [INN]; CAS-92623-83-1; Pravadolinum [INN-Latin]; Pravadolina [INN-Spanish]; AC1Q5EGD; MLS006010335; MLS004774040; SCHEMBL488940; Pravadoline(WIN 48 09
• Cross-matching ID:
  PubChem CID: 56463
  ChEBI ID: CHEMBL13178
  CAS Number: CAS 92623-83-1
  TTD Drug ID: D0L6RT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	1.92	2.16e-2	48/60 (80%)	FTH1;MT1E;MT1G;...
Acute myeloid leukemia	1.86	3.23e-2	66/67 (98.51%)	ITGAM;KIT;DUSP6;...
Viral protein interaction with cytokine and cytokine re...	1.80	3.95e-2	84/100 (84%)	CCL4;ACKR3;CXCL14;...
Valine, leucine and isoleucine degradation	1.79	3.50e-2	42/48 (87.5%)	ACAA1;PCCA;AOX1;...
Ferroptosis	1.75	4.10e-2	36/41 (87.8%)	CP;FTH1;ACSL1;...
p53 signaling pathway	-1.92	3.66e-2	63/73 (86.3%)	TP53;CHEK1;GADD45G;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	8uM	72H	Hide ▲