General Information of Drug (ID: DM3XYD1)

Drug Name
Tegaserod Drug Info
Synonyms Tegaserod (USAN/INN); 1-[[(Z)-(5-methoxyindol-3-ylidene)methyl]amino]-2-pentylguanidine
Cross-matching ID
PubChem CID
135409453
ChEBI ID
CHEMBL76370
CAS Number
CAS 145158-71-0
TTD Drug ID
D00XWD
VARIDT Drug ID
DR00018
INTEDE Drug ID
DR1541

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.22 0.00e+0 19/20 (95%) NSDHL;MSMO1;SQLE;...
TNF signaling pathway 2.21 0.00e+0 103/112 (91.96%) CXCL1;CXCL3;ATF4;...
NF-kappa B signaling pathway 2.16 0.00e+0 90/104 (86.54%) CXCL8;CXCL1;CXCL3;...
IL-17 signaling pathway 2.05 0.00e+0 84/94 (89.36%) CXCL8;CXCL1;CXCL3;...
Protein processing in endoplasmic reticulum 1.95 2.07e-3 127/171 (74.27%) DDIT3;HERPUD1;HSPA6;...
Legionellosis 1.94 5.18e-3 51/57 (89.47%) CXCL8;HSPA6;CXCL1;...
Lipid and atherosclerosis 1.87 7.41e-3 190/215 (88.37%) DDIT3;CXCL8;HSPA6;...
Mineral absorption 1.86 9.07e-3 48/60 (80%) HMOX1;ATP2B1;MT1X;...
Rheumatoid arthritis 1.85 1.04e-2 78/93 (83.87%) CXCL8;VEGFA;CXCL1;...
MAPK signaling pathway 1.84 9.33e-3 272/294 (92.52%) DDIT3;HSPA6;PAK1;...
Mitophagy 1.83 1.04e-2 56/68 (82.35%) SQSTM1;ATF4;EIF2AK3;...
C-type lectin receptor signaling pathway 1.83 1.04e-2 93/104 (89.42%) PAK1;NFKBIA;RELB;...
Viral protein interaction with cytokine and cytokine re... 1.81 1.20e-2 84/100 (84%) CXCL8;CXCL1;CXCL3;...
NOD-like receptor signaling pathway 1.79 1.33e-2 145/181 (80.11%) CXCL8;CXCL1;CXCL3;...
Epithelial cell signaling in Helicobacter pylori infect... 1.78 1.31e-2 62/70 (88.57%) CXCL8;PAK1;CXCL1;...
Osteoclast differentiation 1.77 1.49e-2 117/127 (92.13%) SQSTM1;NFKBIA;RELB;...
Longevity regulating pathway 1.72 2.20e-2 90/151 (59.6%) HSPA6;ATF4;INSR;...
Nicotinate and nicotinamide metabolism 1.71 2.30e-2 25/35 (71.43%) NAMPT;NMRK1;SIRT1;...
ErbB signaling pathway 1.69 2.84e-2 79/85 (92.94%) PAK1;CDKN1A;JUN;...
Neurotrophin signaling pathway 1.65 4.20e-2 107/119 (89.92%) NTRK2;ATF4;NFKBIA;...
B cell receptor signaling pathway 1.64 4.89e-2 71/81 (87.65%) NFKBIA;JUN;BLNK;...
Fat digestion and absorption -1.60 3.99e-2 35/43 (81.4%) PLPP1;PLA2G1B;ABCG5;...
Glutathione metabolism -1.61 4.15e-2 43/57 (75.44%) GSR;GSTT1;RRM1;...
Progesterone-mediated oocyte maturation -1.62 3.81e-2 75/100 (75%) CCNB2;MAPK13;CPEB1;...
Nucleotide excision repair -1.63 3.60e-2 40/47 (85.11%) CCNH;RFC4;PCNA;...
Pentose and glucuronate interconversions -1.64 3.68e-2 17/34 (50%) AKR1A1;UGT2B4;XYLB;...
Base excision repair -1.64 3.58e-2 29/33 (87.88%) PARP1;POLE3;PCNA;...
Caffeine metabolism -1.65 3.57e-2 5/6 (83.33%) NAT2;NAT1
Retinol metabolism -1.66 3.46e-2 41/68 (60.29%) CYP3A4;ALDH1A1;ADH6;...
Pyrimidine metabolism -1.68 3.28e-2 40/56 (71.43%) CTPS2;TK2;NUDT2;...
Homologous recombination -1.69 3.08e-2 35/41 (85.37%) ATM;SEM1;TOP3A;...
Oocyte meiosis -1.71 2.91e-2 90/129 (69.77%) FBXW11;PPP2R1A;PPP3CB;...
Ubiquinone and other terpenoid-quinone biosynthesis -1.71 3.05e-2 9/11 (81.82%) VKORC1;COQ7;COQ2;...
Metabolism of xenobiotics by cytochrome P450 -1.73 2.92e-2 49/77 (63.64%) CYP2E1;CBR1;GSTM4;...
Diabetic cardiomyopathy -1.73 2.86e-2 162/203 (79.8%) PLCB3;RAC2;ATP5PO;...
Huntington disease -1.76 2.06e-2 233/306 (76.14%) MAPK8;PSMD7;PSMD14;...
Proteasome -1.76 2.25e-2 44/46 (95.65%) PSME2;PSMC5;PSMD11;...
Cell cycle -1.78 1.90e-2 110/124 (88.71%) E2F1;CDK6;ESPL1;...
Folate biosynthesis -1.79 2.01e-2 23/26 (88.46%) ALPL;ALPP;PTS;...
Fanconi anemia pathway -1.79 2.26e-2 36/54 (66.67%) TOP3A;REV3L;TOP3B;...
Peroxisome -1.82 1.50e-2 72/82 (87.8%) PEX26;PEX1;ACOT8;...
Thermogenesis -1.87 6.35e-3 173/232 (74.57%) ATP5PO;NDUFS4;ACTL6B;...
Mismatch repair -1.93 1.90e-3 22/23 (95.65%) SSBP1;RFC4;PCNA;...
Drug metabolism -2.03 0.00e+0 78/151 (51.66%) ADH1A;MAOB;NME1;...
Citrate cycle (TCA cycle) -2.18 0.00e+0 30/30 (100%) SDHB;FH;SUCLG1;...
Oxidative phosphorylation -2.26 0.00e+0 93/133 (69.92%) ATP5PO;NDUFS4;COX5A;...
DNA replication -2.35 0.00e+0 34/36 (94.44%) PRIM2;MCM4;RNASEH2B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H