General Information of Drug (ID: DM3YXP8)

Drug Name
Remacemide Drug Info
Synonyms
Remacemida; Remacemidum; Remacemide [INN]; FPL 12924; FPL 12924AA; FPL 14144; FPL 14145; FPL-12944AA; PR 1032-644; PR 934-423; PR1032-646; Remacemida [INN-Spanish]; Remacemidum [INN-Latin]; PR-934-423; Remacemide monohydrochloride, (+-)-isomer; (+)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide; (+-)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide; (-)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide; 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide; 2-amino-N-(1-methyl-1,2-diphenylethyl)acetamide
Cross-matching ID
PubChem CID
60511
ChEBI ID
CHEMBL91654
CAS Number
CAS 128298-28-2
TTD Drug ID
D05JET
INTEDE Drug ID
DR1908

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Endocrine and other factor-regulated calcium reabsorpti... 1.84 1.19e-1 49/53 (92.45%) PRKCB;FXYD2;KLK2;...
GABAergic synapse 1.80 8.09e-2 76/89 (85.39%) PRKCB;GNG12;GABBR1;...
Morphine addiction 1.67 2.34e-1 80/91 (87.91%) PRKCB;GNG12;GABBR1;...
Allograft rejection 1.59 3.75e-1 32/38 (84.21%) CD40;HLA-DOB;HLA-DRB1;...
Sulfur relay system 1.48 4.10e-1 5/8 (62.5%) MPST;NFS1;TST
Oocyte meiosis 1.47 3.76e-1 90/129 (69.77%) SMC1A;PPP2R5A;STAG3;...
Hematopoietic cell lineage 1.47 3.49e-1 90/99 (90.91%) CD55;ITGA6;CD34;...
Nicotine addiction 1.46 3.58e-1 32/40 (80%) SLC17A7;GABRA2;GABRP;...
Cell cycle 1.45 3.48e-1 110/124 (88.71%) SMC1A;CCNB2;BUB1B;...
Ribosome biogenesis in eukaryotes 1.45 3.24e-1 52/108 (48.15%) NOL6;NOP10;IMP3;...
Bacterial invasion of epithelial cells 1.44 3.15e-1 59/77 (76.62%) CAV2;CAV1;PIK3CA;...
RNA polymerase 1.44 2.96e-1 23/31 (74.19%) POLR1C;POLR1D;POLR2C;...
Intestinal immune network for IgA production 1.44 2.93e-1 38/48 (79.17%) CD40;HLA-DOB;CXCR4;...
Aldosterone-regulated sodium reabsorption 1.44 2.78e-1 34/37 (91.89%) SGK1;PRKCB;IRS1;...
Melanogenesis 1.42 2.99e-1 74/101 (73.27%) WNT5A;PRKCB;LEF1;...
Drug metabolism 1.41 2.85e-1 78/151 (51.66%) DPYD;GSTP1;IMPDH2;...
Wnt signaling pathway 1.41 2.95e-1 124/166 (74.7%) WNT5A;NFATC3;PRKCB;...
Bile secretion 1.40 2.86e-1 68/90 (75.56%) SLCO1B3;FXYD2;KCNN2;...
Metabolism of xenobiotics by cytochrome P450 1.40 2.78e-1 49/77 (63.64%) GSTP1;CYP1B1;CYP1A2;...
Transcriptional misregulation in cancer 1.39 3.00e-1 158/192 (82.29%) TSPAN7;HPGD;CD40;...
Ubiquitin mediated proteolysis 1.39 2.91e-1 87/140 (62.14%) SKP2;STUB1;CUL3;...
Serotonergic synapse 1.37 3.07e-1 97/114 (85.09%) PRKCB;GNG12;CYP2C18;...
Primary bile acid biosynthesis 1.37 3.06e-1 15/17 (88.24%) AKR1C4;BAAT;AKR1D1;...
Proteoglycans in cancer 1.37 2.97e-1 172/205 (83.9%) WNT5A;LUM;CAV2;...
Human T-cell leukemia virus 1 infection 1.33 3.80e-1 197/219 (89.95%) NFATC3;CCNB2;BUB1B;...
Caffeine metabolism 1.32 3.70e-1 5/6 (83.33%) CYP1A2;CYP2A6
Type II diabetes mellitus 1.32 3.65e-1 42/46 (91.3%) IRS2;IRS1;PIK3CA;...
Adipocytokine signaling pathway 1.32 3.61e-1 64/69 (92.75%) IRS2;IRS1;NPY;...
VEGF signaling pathway 1.30 3.86e-1 50/59 (84.75%) PRKCB;PIK3CA;SRC;...
Insulin secretion 1.28 4.24e-1 75/86 (87.21%) PRKCB;FXYD2;KCNN2;...
Lysosome -1.22 5.09e-1 115/128 (89.84%) CTSC;NAGPA;HYAL3;...
Insulin resistance -1.22 5.08e-1 96/108 (88.89%) NR1H2;RPS6KB2;CREB1;...
AGE-RAGE signaling pathway in diabetic complications -1.22 5.09e-1 97/100 (97%) SMAD3;COL4A1;IL1A;...
Mucin type O-glycan biosynthesis -1.23 5.16e-1 20/36 (55.56%) ST3GAL1;ST3GAL2;GALNT8;...
Phagosome -1.23 5.09e-1 118/152 (77.63%) MRC2;FCGR2A;ATP6AP1;...
TGF-beta signaling pathway -1.23 5.08e-1 81/94 (86.17%) PPP2R1A;TGIF2;BMPR2;...
NOD-like receptor signaling pathway -1.24 5.03e-1 145/181 (80.11%) IRAK4;GBP2;IFNAR1;...
Human papillomavirus infection -1.24 5.13e-1 284/331 (85.8%) TSC2;COL6A2;TLR3;...
Necroptosis -1.24 5.17e-1 113/159 (71.07%) IFNAR1;IFNGR2;SHARPIN;...
ECM-receptor interaction -1.25 5.24e-1 80/88 (90.91%) COL6A2;ITGAV;COL9A1;...
One carbon pool by folate -1.26 5.17e-1 15/20 (75%) ALDH1L1;DHFR;MTHFD2;...
Glutathione metabolism -1.27 4.98e-1 43/57 (75.44%) GSTT1;PRDX6;GCLM;...
Thiamine metabolism -1.27 4.89e-1 12/15 (80%) AK1;AK4
Steroid biosynthesis -1.28 4.93e-1 19/20 (95%) CYP2R1;FDFT1;SOAT1;...
Tuberculosis -1.28 5.02e-1 159/180 (88.33%) IL10RB;MRC2;BID;...
Cytokine-cytokine receptor interaction -1.28 5.15e-1 246/295 (83.39%) BMP7;IL1RL1;CCL5;...
Fatty acid degradation -1.29 5.24e-1 40/43 (93.02%) ACADL;ECHS1;ADH1C;...
Diabetic cardiomyopathy -1.31 5.00e-1 162/203 (79.8%) TGFBR2;COX5B;SMAD2;...
Malaria -1.32 5.07e-1 44/50 (88%) THBS2;ITGAL;ACKR1;...
Renin-angiotensin system -1.32 5.24e-1 20/23 (86.96%) LNPEP;ANPEP;ACE2;...
Circadian rhythm -1.33 5.16e-1 26/31 (83.87%) CSNK1E;BHLHE40;PRKAA1;...
TNF signaling pathway -1.41 4.93e-1 103/112 (91.96%) NOD2;PIK3R3;CX3CL1;...
Ascorbate and aldarate metabolism -1.41 5.23e-1 15/30 (50%) UGT2A3;ALDH7A1;ALDH3A2;...
Neomycin, kanamycin and gentamicin biosynthesis -1.52 3.90e-1 5/5 (100%) HK1;HK3;HK2
Legionellosis -1.53 4.24e-1 51/57 (89.47%) HSF1;RAB1B;IL18;...
Mineral absorption -1.58 3.29e-1 48/60 (80%) MT1E;SLC39A4;ATP1A2;...
PPAR signaling pathway -1.59 3.91e-1 66/74 (89.19%) PLTP;ACAA1;CPT1A;...
Starch and sucrose metabolism -1.62 3.87e-1 25/36 (69.44%) HK1;PYGM;GAA;...
Ferroptosis -1.72 1.87e-1 36/41 (87.8%) SLC3A2;CP;TP53;...
Amino sugar and nucleotide sugar metabolism -1.72 3.65e-1 38/48 (79.17%) NPL;HEXB;HK1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H