Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3Z2JB)

Drug Name
GDC-0349 Drug Info
Synonyms MTORC1/2 inhibitors
Cross-matching ID
PubChem CID
59239165
ChEBI ID
CHEMBL2331680
CAS Number
CAS 1207360-89-1
TTD Drug ID
D0U8QH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Other glycan degradation 1.89 2.81e-2 13/18 (72.22%) HEXA;HEXB;MAN2C1;...
Biosynthesis of unsaturated fatty acids -1.59 4.30e-2 21/27 (77.78%) ELOVL1;ELOVL6;ACOX3;...
Steroid biosynthesis -1.61 3.58e-2 19/20 (95%) LBR;HSD17B7;EBP;...
Protein export -1.62 3.40e-2 17/23 (73.91%) SRP9;SPCS1;SEC61G;...
Alzheimer disease -1.63 3.18e-2 279/369 (75.61%) PIK3R1;DKK4;COX6C;...
Mismatch repair -1.63 3.30e-2 22/23 (95.65%) POLD3;RPA2;RFC2;...
Autoimmune thyroid disease -1.66 2.50e-2 46/53 (86.79%) IL2;CD40LG;HLA-DPA1;...
Type I diabetes mellitus -1.66 2.51e-2 38/43 (88.37%) IFNG;HLA-B;PRF1;...
IL-17 signaling pathway -1.68 2.39e-2 84/94 (89.36%) CSF3;TRAF4;TNFAIP3;...
Oxidative phosphorylation -1.71 1.88e-2 93/133 (69.92%) ATP6V1A;SDHD;ATP6V1B1;...
Glutathione metabolism -1.73 1.61e-2 43/57 (75.44%) GSS;GPX1;GSTA1;...
Legionellosis -1.74 1.53e-2 51/57 (89.47%) RAB1A;HSPA1A;CASP3;...
Non-alcoholic fatty liver disease -1.75 1.45e-2 126/155 (81.29%) PIK3R1;COX6C;IL1B;...
Epstein-Barr virus infection -1.76 1.29e-2 189/202 (93.56%) SAP30;PIK3R1;CDK6;...
Glycine, serine and threonine metabolism -1.76 1.37e-2 31/40 (77.5%) GATM;BPGM;AOC3;...
Spliceosome -1.76 1.46e-2 101/150 (67.33%) SNRNP27;PRPF31;PRPF38B;...
Graft-versus-host disease -1.78 1.20e-2 32/42 (76.19%) HLA-DRB1;HLA-G;KLRD1;...
Cell cycle -1.78 1.29e-2 110/124 (88.71%) ORC5;MCM5;ORC4;...
p53 signaling pathway -1.80 7.33e-3 63/73 (86.3%) IGF1;GADD45G;GTSE1;...
Antigen processing and presentation -1.81 7.94e-3 60/78 (76.92%) NFYB;HLA-DRB1;HLA-G;...
Spinocerebellar ataxia -1.81 8.66e-3 128/143 (89.51%) VDAC3;MAPK10;TBP;...
Allograft rejection -1.81 9.53e-3 32/38 (84.21%) IL2;CD40LG;HLA-DPA1;...
Ubiquinone and other terpenoid-quinone biosynthesis -1.86 4.70e-3 9/11 (81.82%) GGCX;COQ2;COQ3;...
Folate biosynthesis -1.91 3.97e-3 23/26 (88.46%) GGH;QDPR;ALPL;...
Huntington disease -1.96 3.02e-3 233/306 (76.14%) COX6A1;ATP5F1C;CLTB;...
Amyotrophic lateral sclerosis -2.04 0.00e+0 267/364 (73.35%) COX6C;DCTN3;CHMP2B;...
Parkinson disease -2.06 0.00e+0 176/249 (70.68%) KIF5C;ATP5PF;KLC2;...
Prion disease -2.12 0.00e+0 209/273 (76.56%) KIF5C;ATP5PF;KLC2;...
DNA replication -2.13 0.00e+0 34/36 (94.44%) RPA1;POLD2;POLD1;...
Protein processing in endoplasmic reticulum -2.29 0.00e+0 127/171 (74.27%) SEC24A;MAN1A2;NPLOC4;...
Proteasome -2.68 0.00e+0 44/46 (95.65%) PSMD6;PSMA2;PSMA5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 3.33uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H