Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3ZGBH)

Drug Name
Coumaricacid Drug Info
Cross-matching ID
TTD Drug ID
D0BT3Y

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Leishmaniasis -1.72 4.70e-2 67/77 (87.01%) FCGR1A;MAP3K7;MAPK11;...
Protein digestion and absorption -1.73 4.60e-2 78/103 (75.73%) COL1A2;COL1A1;COL5A1;...
PPAR signaling pathway -1.75 3.98e-2 66/74 (89.19%) PPARG;OLR1;SCP2;...
Glycolysis / Gluconeogenesis -1.77 4.27e-2 56/67 (83.58%) PFKP;AKR1A1;PCK2;...
beta-Alanine metabolism -1.78 4.68e-2 25/30 (83.33%) ALDH3A1;CNDP2;DPYD;...
Porphyrin and chlorophyll metabolism -1.86 2.97e-2 23/43 (53.49%) FXN;HMBS;HEPH;...
Pentose and glucuronate interconversions -1.87 4.46e-2 17/34 (50%) UGDH;AKR1A1;AKR1B10;...
Proximal tubule bicarbonate reclamation -1.98 0.00e+0 21/23 (91.3%) GLUD2;ATP1B4;ATP1A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H