Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM3ZNF9)

Drug Name
JNJ-1661010 Drug Info
Synonyms
681136-29-8; JNJ-1661010; JNJ 1661010; JNJ1661010; N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; UNII-62521S57AU; 1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-; N-PHENYL-4-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)-1-PIPERAZINECARBOXAMIDE; CHEMBL460273; 62521S57AU; BHBOSTKQCZEAJM-UHFFFAOYSA-N; ACMC-20emff; AC1MDCTI; AC1Q5LMB; Oprea1_746619; MLS001111246; SCHEMBL1164398; GTPL5206; CTK1J2536; cid_2809273; DTXSID00384599; MolPort-001-806-365; HMS3651L15; HMS1662H10; HMS2801K13; BCP06935; EX-A2218
Cross-matching ID
PubChem CID
2809273
ChEBI ID
CHEMBL460273
CAS Number
CAS 681136-29-8
TTD Drug ID
D0W5WG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
C-type lectin receptor signaling pathway 2.05 1.23e-2 93/104 (89.42%) PAK1;SRC;IKBKE;...
Bacterial invasion of epithelial cells 1.93 2.47e-2 59/77 (76.62%) SRC;CDH1;PIK3CD;...
T cell receptor signaling pathway 1.92 1.64e-2 93/104 (89.42%) PAK1;CD3D;LCK;...
Yersinia infection 1.90 1.85e-2 120/137 (87.59%) SRC;MAP2K6;LCK;...
Primary immunodeficiency 1.84 2.96e-2 33/38 (86.84%) IL7R;CD3D;LCK;...
Fc epsilon RI signaling pathway 1.81 3.29e-2 57/68 (83.82%) ALOX5AP;MAP2K6;PIK3CD;...
VEGF signaling pathway 1.79 3.00e-2 50/59 (84.75%) SRC;VEGFA;PIK3CD;...
Regulation of actin cytoskeleton 1.77 3.24e-2 185/218 (84.86%) PAK1;SRC;ITGB7;...
Toll-like receptor signaling pathway 1.75 3.43e-2 94/104 (90.38%) IKBKE;CCL5;MAP2K6;...
Melanogenesis 1.75 3.08e-2 74/101 (73.27%) CREB3L1;DCT;PLCB1;...
Sulfur metabolism 1.71 4.82e-2 9/10 (90%) PAPSS2;ETHE1;SQOR;...
Regulation of lipolysis in adipocytes -1.60 4.84e-2 52/55 (94.55%) ABHD5;LIPE;NPR1;...
Peroxisome -1.62 4.45e-2 72/82 (87.8%) MLYCD;HSD17B4;PEX12;...
N-Glycan biosynthesis -1.64 3.57e-2 38/50 (76%) MGAT2;GANAB;B4GALT3;...
Fatty acid elongation -1.64 3.75e-2 19/27 (70.37%) MECR;ELOVL1;HADHB;...
Propanoate metabolism -1.66 3.47e-2 30/34 (88.24%) ECHS1;BCKDHA;HADHA;...
Pyruvate metabolism -1.68 3.38e-2 41/47 (87.23%) AKR1A1;MDH2;DLAT;...
Metabolism of xenobiotics by cytochrome P450 -1.69 3.47e-2 49/77 (63.64%) ADH1A;CYP3A5;HPGDS;...
Drug metabolism -1.70 3.09e-2 78/151 (51.66%) CES1;IMPDH1;CES2;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -1.72 2.70e-2 20/26 (76.92%) PIGV;PGAP1;PIGH;...
Glycerolipid metabolism -1.74 2.31e-2 44/61 (72.13%) PLPP3;AKR1A1;LIPC;...
Arginine biosynthesis -1.74 2.60e-2 17/22 (77.27%) GOT1;CPS1;ARG2;...
Glyoxylate and dicarboxylate metabolism -1.79 1.98e-2 23/30 (76.67%) ACO2;GRHPR;AMT;...
PPAR signaling pathway -1.83 1.80e-2 66/74 (89.19%) LPL;SLC27A2;NR1H3;...
Fat digestion and absorption -1.84 1.85e-2 35/43 (81.4%) AGPAT2;PLA2G1B;ABCG5;...
Fatty acid degradation -1.93 5.79e-3 40/43 (93.02%) ACADVL;HADHB;ADH1A;...
Retinol metabolism -1.93 7.71e-3 41/68 (60.29%) ADH1A;CYP3A5;CYP2C8;...
Complement and coagulation cascades -1.97 3.86e-3 76/85 (89.41%) CFHR2;SERPIND1;C2;...
Valine, leucine and isoleucine degradation -2.02 0.00e+0 42/48 (87.5%) HADHB;MCCC1;HMGCL;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H