Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM40TBU)

Drug Name
COUMESTROL Drug Info
Synonyms
COUMESTROL; 479-13-0; Cumoestrol; Cumoesterol; Cumostrol; Coumesterol; 3,9-Dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one; 7,12-Dihydroxycoumestan; 3,9-Dihydroxycoumestan; UNII-V7NW98OB34; NSC 22842; CCRIS 7311; NSC22842; 6H-Benzofuro[3,2-c][1]benzopyran-6-one, 3,9-dihydroxy-; EINECS 207-525-6; BRN 0266702; CHEMBL30707; MLS000738006; V7NW98OB34; CHEBI:3908; ZZIALNLLNHEQPJ-UHFFFAOYSA-N; 3,9-Dihydroxy-6H-benzofuro(3,2-c)(1)benzopyran-6-one; 6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 3,9-dihydroxy-
Cross-matching ID
PubChem CID
5281707
ChEBI ID
CHEMBL30707
CAS Number
CAS 479-13-0
TTD Drug ID
D02DML
VARIDT Drug ID
DR00932

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Dilated cardiomyopathy 1.92 1.12e-2 86/96 (89.58%) GNAS;TGFB1;ADCY9;...
Amino sugar and nucleotide sugar metabolism -1.64 4.74e-2 38/48 (79.17%) HK1;CHIT1;GMPPA;...
Arginine and proline metabolism -1.68 3.61e-2 39/50 (78%) DAO;ODC1;CNDP2;...
Mineral absorption -1.70 3.29e-2 48/60 (80%) MT1G;FTH1;MT1HL1;...
Peroxisome -1.70 3.57e-2 72/82 (87.8%) ABCD1;PEX26;PIPOX;...
Drug metabolism -1.70 3.74e-2 78/151 (51.66%) ADH1C;TPMT;DPYS;...
Arginine biosynthesis -1.72 3.25e-2 17/22 (77.27%) ASS1;OTC;GLUL;...
Histidine metabolism -1.75 2.66e-2 16/22 (72.73%) CNDP2;HAL;ASPA;...
beta-Alanine metabolism -1.75 3.00e-2 25/30 (83.33%) DPYS;AOC3;CNDP2;...
Circadian rhythm -1.77 2.94e-2 26/31 (83.87%) PRKAA1;CSNK1D;RORA;...
Metabolism of xenobiotics by cytochrome P450 -1.77 3.42e-2 49/77 (63.64%) ADH1C;CYP2D6;GSTA3;...
Primary bile acid biosynthesis -1.79 3.25e-2 15/17 (88.24%) ACOX2;BAAT;AKR1C4;...
Phenylalanine metabolism -1.84 2.35e-2 14/17 (82.35%) MIF;DDC;AOC2;...
Other glycan degradation -1.92 1.14e-2 13/18 (72.22%) MAN2B1;AGA;NEU1;...
Complement and coagulation cascades -2.07 0.00e+0 76/85 (89.41%) F3;C8A;CR2;...
Tyrosine metabolism -2.11 0.00e+0 30/36 (83.33%) ADH1C;AOC3;HPD;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H