Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM42HXN)

Drug Name
Atracurium Drug Info
Synonyms
Atracurium Dibesylate; Tracrium (TN); 2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium]; 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
Therapeutic ClassNeuromuscular Nondepolarizing Agents
Cross-matching ID
PubChem CID
47319
ChEBI ID
CHEMBL1360
CAS Number
CAS 64228-79-1
TTD Drug ID
D0Q1PR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
NF-kappa B signaling pathway -1.68 4.81e-2 90/104 (86.54%) VCAM1;TRAF6;CSNK2B;...
Legionellosis -1.70 3.74e-2 51/57 (89.47%) HSPA1A;NFKB1;HSPA6;...
Complement and coagulation cascades -1.71 3.85e-2 76/85 (89.41%) C8B;CPB2;F8;...
Glyoxylate and dicarboxylate metabolism -1.71 4.07e-2 23/30 (76.67%) HYI;SHMT2;AGXT;...
Prion disease -1.74 3.17e-2 209/273 (76.56%) C1QA;CREB3L1;NDUFS1;...
Non-alcoholic fatty liver disease -1.75 3.37e-2 126/155 (81.29%) TNFRSF1A;NDUFS6;COX6C;...
Thermogenesis -1.75 3.75e-2 173/232 (74.57%) ATP5MC3;NDUFA5;CREB3L2;...
Arginine biosynthesis -1.77 3.64e-2 17/22 (77.27%) GLUD2;GOT2;OTC;...
Mineral absorption -1.77 3.82e-2 48/60 (80%) SLC30A1;MT2A;STEAP1;...
Primary bile acid biosynthesis -1.80 3.30e-2 15/17 (88.24%) AKR1C4;CYP7A1;BAAT;...
Linoleic acid metabolism -1.80 3.96e-2 21/29 (72.41%) PLA2G12A;CYP1A2;CYP2C8;...
Oxidative phosphorylation -1.89 1.75e-2 93/133 (69.92%) ATP5MC3;NDUFA5;COX10;...
Parkinson disease -1.91 1.94e-2 176/249 (70.68%) NDUFS1;NDUFA9;RPS27A;...
Retinol metabolism -1.94 2.33e-2 41/68 (60.29%) DHRS9;CYP3A5;CYP3A7;...
Ribosome -2.28 0.00e+0 113/158 (71.52%) RPS15;RPS10;MRPS16;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 3.33uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H