Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM43O2U)

Drug Name
Z-Pro-Prolinal Drug Info
Synonyms
Z-Pro-prolinal; N-Benzyloxycarbonyl-prolyl-prolinal; n-benzyloxycarbonyl-l-prolyl-l-prolinal; CHEMBL79993; BRN 4821785; Prolyl Endopeptidase Inhibitor II; 86925-97-5; z-prolyl-prolinal; benzyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate; ZPR; 2-Pyrrolidinecarboxylic acid, 2-((2-formyl-1-pyrrolidinyl)carbonyl)-, phenylmethyl ester, (S-(R*,R*))-; AC1L3UY7; AC1Q6A8G; KBioSS_000265; KBioGR_000265; BSPBio_001545; SCHEMBL1219336; KBio3_000529; KBio2_005401; KBio3_000530; KBio2_002833; KBio2_000265; CTK3E8930
Cross-matching ID
PubChem CID
122623
ChEBI ID
CHEMBL79993
CAS Number
CAS 88795-32-8
TTD Drug ID
D06FNK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Leukocyte transendothelial migration -1.68 4.85e-2 90/114 (78.95%) NCF4;GNAI1;RAP1A;...
Aldosterone-regulated sodium reabsorption -1.69 4.44e-2 34/37 (91.89%) SFN;PIK3CA;SGK1;...
Rheumatoid arthritis -1.69 4.57e-2 78/93 (83.87%) LTB;HLA-DRB1;ATP6V1B1;...
Steroid biosynthesis -1.73 3.44e-2 19/20 (95%) LIPA;LSS;DHCR24;...
Sulfur metabolism -1.73 3.51e-2 9/10 (90%) TST;SELENBP1;PAPSS2
PPAR signaling pathway -1.74 3.38e-2 66/74 (89.19%) SORBS1;APOA1;FABP3;...
p53 signaling pathway -1.76 2.88e-2 63/73 (86.3%) ATM;PMAIP1;GADD45A;...
Valine, leucine and isoleucine degradation -1.83 1.78e-2 42/48 (87.5%) EHHADH;ACADM;ACADS;...
Protein digestion and absorption -1.85 7.05e-3 78/103 (75.73%) COL5A1;SLC1A5;PRCP;...
Propanoate metabolism -1.88 4.76e-3 30/34 (88.24%) LDHA;EHHADH;ACADS;...
Fat digestion and absorption -1.92 3.62e-3 35/43 (81.4%) PLPP3;FABP1;ACAT1;...
Pantothenate and CoA biosynthesis -1.92 4.23e-3 14/21 (66.67%) PPCS;AASDHPPT;BCAT1;...
Citrate cycle (TCA cycle) -1.95 5.07e-3 30/30 (100%) PDHA1;DLST;SDHC;...
African trypanosomiasis -1.95 6.34e-3 32/37 (86.49%) ICAM1;FAS;PLCB3;...
Pyruvate metabolism -1.95 8.46e-3 41/47 (87.23%) ME3;PDHA1;MDH2;...
Oxidative phosphorylation -1.98 1.27e-2 93/133 (69.92%) NDUFS8;COX11;ATP5PB;...
Synthesis and degradation of ketone bodies -2.07 0.00e+0 9/10 (90%) HMGCS1;HMGCS2;ACAT1
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 15uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H