Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM459Q7)

• Drug Name: BMS-833923 Drug Info
• Synonyms: BMS-833923; 1059734-66-5; BMS 833923; XL139; XL 139; BMS833923; UNII-41J7ZJ239R; N-(2-Methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide; 41J7ZJ239R; XL-139; C30H27N5O; N-(2-methyl-5-((methylamino)methyl)phenyl)-4-(4-phenylquinazolin-2-ylamino)benzamide; Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-; BMS-833923 free base anhydrous; XL139 mesylate; SCHEMBL4138073; GTPL8202; CHEMBL3545403; EX-A789; MolPort-035-395-837; HMS3653O09; BCP07837; AOB87352
• Cross-matching ID:
  PubChem CID: 57662985
  CAS Number: CAS 1059734-66-5
  TTD Drug ID: D03DUY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
IL-17 signaling pathway	2.16	0.00e+0	84/94 (89.36%)	IKBKE;JUN;FOS;...
Spliceosome	2.10	0.00e+0	101/150 (67.33%)	HSPA1A;SRSF7;HNRNPA1;...
Steroid biosynthesis	2.08	0.00e+0	19/20 (95%)	SQLE;NSDHL;LSS;...
Ribosome biogenesis in eukaryotes	1.90	5.64e-3	52/108 (48.15%)	NOP56;FBL;DKC1;...
Nicotine addiction	1.77	4.29e-2	32/40 (80%)	GABRP;GABRG2;GRIN2A;...
Type II diabetes mellitus	1.77	3.57e-2	42/46 (91.3%)	HK2;IRS2;PKM;...
Thermogenesis	-1.68	4.64e-2	173/232 (74.57%)	SMARCD2;FGFR1;UCP1;...
p53 signaling pathway	-1.68	4.96e-2	63/73 (86.3%)	CCNE1;CCNG1;PMAIP1;...
Steroid hormone biosynthesis	-1.72	3.20e-2	43/61 (70.49%)	HSD17B8;CYP11A1;CYP21A2;...
Propanoate metabolism	-1.74	2.70e-2	30/34 (88.24%)	MMUT;BCKDHB;HADHA;...
D-Glutamine and D-glutamate metabolism	-1.75	2.50e-2	5/5 (100%)	GLUD1;GLS2;GLUD2;...
Valine, leucine and isoleucine degradation	-1.75	2.82e-2	42/48 (87.5%)	ALDH6A1;ACADS;HSD17B10;...
Folate biosynthesis	-1.80	1.55e-2	23/26 (88.46%)	PCBD1;QDPR;MOCS2;...
Diabetic cardiomyopathy	-1.83	1.35e-2	162/203 (79.8%)	TGFB3;NDUFB1;NDUFA1;...
Arginine biosynthesis	-1.84	1.26e-2	17/22 (77.27%)	ASL;GOT1;OTC;...
Fatty acid degradation	-1.84	1.58e-2	40/43 (93.02%)	ACADVL;ACADM;ACSL5;...
Arachidonic acid metabolism	-1.88	1.20e-2	48/61 (78.69%)	PTGS2;CYP2E1;CYP2C8;...
ECM-receptor interaction	-1.89	1.80e-2	80/88 (90.91%)	COL9A1;TNN;ITGA3;...
Oxidative phosphorylation	-2.14	0.00e+0	93/133 (69.92%)	NDUFB1;NDUFA1;ATP5PO;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Show ▼