Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM46F5X)

Drug Name
isobutylmethylxanthine Drug Info
Synonyms
3-Isobutyl-1-methylxanthine; IBMX; 28822-58-4; 1-METHYL-3-ISOBUTYLXANTHINE; Methylisobutylxanthine; 3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione; Xanthine, 3-isobutyl-1-methyl-; 3-Isobutyl-1-methyxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-; Methyl-isobutylxanthine; 3-isobutyl-1-methylxanthine (ibmx); UNII-TBT296U68M; 3-Isobutyl 1-methylxanthine; NSC 165960; CCRIS 4290; CHEBI:34795; 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione; 3-isobutyl-1-methyl-7H-xanthine; methylisobutylxanthine; 3-Isobutyl-1-methyl-3,9-dihydro-purine-2,6-dione; 3-ISOBUTYL-1-METHYLXANTHINE
Cross-matching ID
PubChem CID
3758
ChEBI ID
CHEMBL275084
CAS Number
CAS 28822-58-4
TTD Drug ID
D0R6MT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Allograft rejection 2.09 9.34e-3 32/38 (84.21%) HLA-DQA1;HLA-DQB1;HLA-DPB1;...
Type I diabetes mellitus 1.98 9.34e-3 38/43 (88.37%) HLA-DQA1;HLA-DQB1;HLA-DPB1;...
Autoimmune thyroid disease 1.94 9.34e-3 46/53 (86.79%) HLA-DQA1;HLA-DQB1;HLA-DPB1;...
Graft-versus-host disease 1.94 7.00e-3 32/42 (76.19%) HLA-DQA1;HLA-DQB1;HLA-DPB1;...
Viral myocarditis 1.93 7.47e-3 53/60 (88.33%) HLA-DQA1;HLA-DQB1;HLA-DPB1;...
Leishmaniasis 1.92 6.22e-3 67/77 (87.01%) HLA-DQA1;MARCKSL1;HLA-DQB1;...
Spliceosome 1.86 1.20e-2 101/150 (67.33%) LSM5;PRPF40A;SNRPE;...
Asthma 1.86 1.05e-2 25/31 (80.65%) HLA-DQA1;HLA-DQB1;HLA-DPB1;...
Intestinal immune network for IgA production 1.80 1.35e-2 38/48 (79.17%) HLA-DQA1;HLA-DQB1;HLA-DPB1;...
Proximal tubule bicarbonate reclamation 1.79 1.21e-2 21/23 (91.3%) AQP1;PCK1;SLC4A4;...
Collecting duct acid secretion -1.81 3.17e-2 22/27 (81.48%) ATP6V1G1;ATP4B;ATP6V0A2;...
Galactose metabolism -1.83 3.88e-2 26/31 (83.87%) G6PC3;UGP2;GLA;...
Vibrio cholerae infection -1.92 2.64e-2 44/50 (88%) ATP6V1G1;ATP6V0A2;PRKACA;...
Epithelial cell signaling in Helicobacter pylori infect... -1.97 3.17e-2 62/70 (88.57%) IKBKB;MAPK14;MAPK11;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 15uM 72H