Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM471IG)

Drug Name
SR-33805 Drug Info
Synonyms
SR 33805; 121345-64-0; AC1L2VL6; SCHEMBL7268066; CHEMBL287679; DTXSID40153241; 3,4-Dimethoxy-N-methyl-N(3-(4-((1-methyl-2-(1-methylethyl)-1H-indol-3-yl)sulfonyl)phenoxy)propyl)benzeneethanamine; N-[3-[4-[(1-Methyl-2-isopropyl-1H-indol-3-yl)sulfonyl]phenoxy]propyl]-N-methyl-3,4-dimethoxyphenethylamine; N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-3-[4-(1-methyl-2-propan-2-ylindol-3-yl)sulfonylphenoxy]propan-1-amine; Benzeneethanamine, 3,4-dimethoxy-N-methyl-N(3-(4-((1-methyl-2-(1-methylethyl)-1H-indol-3-yl)sulfonyl)phen
Cross-matching ID
PubChem CID
9850876
TTD Drug ID
D0A8ZD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.11 0.00e+0 48/60 (80%) MT1H;MT1HL1;MT1E;...
Retinol metabolism 2.06 0.00e+0 41/68 (60.29%) AOX1;PNPLA4;ADH1C;...
Butanoate metabolism 2.00 0.00e+0 23/28 (82.14%) ACAT2;BDH2;HMGCS2;...
Synthesis and degradation of ketone bodies 1.91 0.00e+0 9/10 (90%) ACAT2;BDH2;HMGCS2;...
Metabolism of xenobiotics by cytochrome P450 1.90 0.00e+0 49/77 (63.64%) CYP1B1;ADH1C;HSD11B1;...
Peroxisome 1.85 7.19e-3 72/82 (87.8%) IDH1;ACSL3;PIPOX;...
Steroid biosynthesis 1.82 8.63e-3 19/20 (95%) MSMO1;DHCR24;FDFT1;...
Glycolysis / Gluconeogenesis 1.82 8.63e-3 56/67 (83.58%) ALDOC;ALDOB;HK2;...
Pentose and glucuronate interconversions 1.81 7.67e-3 17/34 (50%) SORD;AKR1B10;UGP2;...
Drug metabolism 1.79 9.49e-3 78/151 (51.66%) HPRT1;AOX1;FMO2;...
PPAR signaling pathway 1.76 1.73e-2 66/74 (89.19%) FABP7;SCD;LPL;...
Terpenoid backbone biosynthesis 1.75 1.94e-2 18/22 (81.82%) ACAT2;HMGCR;HMGCS2;...
Arginine biosynthesis 1.74 2.12e-2 17/22 (77.27%) ASS1;GLUL;CPS1;...
Alanine, aspartate and glutamate metabolism 1.70 2.71e-2 27/37 (72.97%) ASS1;GLUL;CPS1;...
Proximal tubule bicarbonate reclamation 1.68 3.39e-2 21/23 (91.3%) AQP1;ATP1B2;SLC4A4;...
Valine, leucine and isoleucine degradation 1.67 3.34e-2 42/48 (87.5%) ACAT2;ALDH6A1;AOX1;...
Oxidative phosphorylation 1.67 3.30e-2 93/133 (69.92%) ATP5MC2;COX7C;COX5B;...
Tyrosine metabolism 1.65 4.17e-2 30/36 (83.33%) AOX1;MIF;ADH1C;...
Ribosome 1.64 4.13e-2 113/158 (71.52%) MRPS16;RPS25;RPL14;...
Steroid hormone biosynthesis 1.63 4.57e-2 43/61 (70.49%) HSD17B2;CYP1B1;HSD11B1;...
Ferroptosis 1.62 4.64e-2 36/41 (87.8%) TF;ACSL3;STEAP3;...
Glyoxylate and dicarboxylate metabolism 1.62 4.59e-2 23/30 (76.67%) ACAT2;GLUL;MDH1;...
Graft-versus-host disease -1.85 8.88e-3 32/42 (76.19%) HLA-DRB1;HLA-C;KLRD1;...
Allograft rejection -1.89 1.18e-2 32/38 (84.21%) HLA-DRB1;HLA-C;CD40LG;...
Systemic lupus erythematosus -1.95 5.92e-3 45/135 (33.33%) SNRPB;HLA-DOA;ACTN4;...
DNA replication -2.11 0.00e+0 34/36 (94.44%) POLE2;POLD2;MCM5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H