Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM471KJ)

Drug Name
Omeprazole Drug Info
Synonyms Losec (TN)
Therapeutic ClassAntiulcer Agents
Cross-matching ID
PubChem CID
4594
ChEBI ID
CHEMBL1503
CAS Number
CAS 73590-58-6
TTD Drug ID
D01XNB
VARIDT Drug ID
DR00387
INTEDE Drug ID
DR1196
ACDINA Drug ID
D00489

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.01 5.18e-3 52/108 (48.15%) NVL;RPP38;RPP40;...
Fanconi anemia pathway 1.97 2.59e-3 36/54 (66.67%) HES1;FANCL;CENPX;...
DNA replication 1.94 1.73e-3 34/36 (94.44%) POLE2;RFC5;POLD3;...
Ribosome 1.86 9.07e-3 113/158 (71.52%) RPS4Y1;MRPL16;MRPL18;...
RNA polymerase 1.78 2.18e-2 23/31 (74.19%) POLR2I;POLR3G;POLR3E;...
Mismatch repair 1.76 2.42e-2 22/23 (95.65%) RFC5;POLD3;RFC4;...
Homologous recombination 1.71 3.55e-2 35/41 (85.37%) POLD3;RAD54B;RBBP8;...
Choline metabolism in cancer -1.65 3.19e-2 84/98 (85.71%) RAC1;DGKA;MAPK8;...
Neurotrophin signaling pathway -1.65 3.15e-2 107/119 (89.92%) SHC1;IKBKB;GRB2;...
Coronavirus disease -1.65 3.25e-2 215/232 (92.67%) MAPK11;EGFR;RPS26;...
Glucagon signaling pathway -1.66 3.26e-2 89/107 (83.18%) GCGR;PYGM;PHKG2;...
HIF-1 signaling pathway -1.67 3.28e-2 105/109 (96.33%) HK3;IFNGR2;ERBB2;...
Non-small cell lung cancer -1.69 3.05e-2 70/72 (97.22%) GRB2;PRKCA;DDB2;...
Amoebiasis -1.72 1.78e-2 99/102 (97.06%) FN1;SERPINB10;PRKACA;...
Lipid and atherosclerosis -1.73 1.66e-2 190/215 (88.37%) MAPK3;HSPA2;IL1B;...
NOD-like receptor signaling pathway -1.73 1.73e-2 145/181 (80.11%) NFKBIB;DEFB4A;NAIP;...
Glioma -1.74 1.74e-2 67/75 (89.33%) SHC1;GRB2;PRKCA;...
Small cell lung cancer -1.74 1.83e-2 90/92 (97.83%) GADD45G;LAMB3;RELA;...
Legionellosis -1.74 1.93e-2 51/57 (89.47%) NAIP;BCL2L13;NFKB1;...
Estrogen signaling pathway -1.75 1.95e-2 119/137 (86.86%) CREB3L1;GABBR2;SP1;...
Synaptic vesicle cycle -1.77 1.62e-2 63/78 (80.77%) ATP6V0D1;RAB3A;ATP6V1E1;...
AGE-RAGE signaling pathway in diabetic complications -1.78 1.62e-2 97/100 (97%) MAPK8;PIM1;TGFBR2;...
Chagas disease -1.78 1.73e-2 93/102 (91.18%) SERPINE1;KNG1;MAPK3;...
Chemokine signaling pathway -1.80 1.53e-2 163/192 (84.9%) MAPK3;CRKL;RAC3;...
Malaria -1.80 1.41e-2 44/50 (88%) THBS2;GYPA;COMP;...
Neutrophil extracellular trap formation -1.81 1.40e-2 101/189 (53.44%) HDAC5;C5AR1;HDAC1;...
Endometrial cancer -1.82 1.53e-2 56/58 (96.55%) GRB2;DDB2;MAPK3;...
Bladder cancer -1.82 1.53e-2 40/41 (97.56%) DAPK1;DAPK2;EGFR;...
Salivary secretion -1.83 1.36e-2 76/93 (81.72%) HTN3;PRKACA;CST5;...
Colorectal cancer -1.85 1.33e-2 84/86 (97.67%) MAPK3;RAC3;BAD;...
Pancreatic cancer -1.87 1.09e-2 75/76 (98.68%) RAC1;MAPK8;TGFBR2;...
Thyroid hormone signaling pathway -1.88 5.09e-3 112/121 (92.56%) ATP2A1;MAPK3;BAD;...
Hepatitis C -1.91 0.00e+0 139/157 (88.54%) BAD;IFNA21;CLDN9;...
Viral protein interaction with cytokine and cytokine re... -1.93 0.00e+0 84/100 (84%) CCL17;CCR10;CSF1R;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.95 0.00e+0 79/89 (88.76%) MAPK3;PTPN11;RASGRP1;...
Measles -1.99 0.00e+0 133/139 (95.68%) HSPA2;CD209;IL1B;...
Lysosome -2.03 0.00e+0 115/128 (89.84%) ENTPD4;LIPA;CTSD;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 15uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H