General Information of Drug (ID: DM47BEG)

Drug Name
(3R,4S)-293B Drug Info
Synonyms LS-185874
Cross-matching ID
PubChem CID
121846
ChEBI ID
CHEMBL434045
CAS Number
CAS 163163-23-3
TTD Drug ID
D01JJH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.05 5.93e-3 113/158 (71.52%) MRPL15;MRPL23;RPL10;...
DNA replication 2.01 5.93e-3 34/36 (94.44%) POLE2;MCM6;SSBP1;...
Homologous recombination 1.89 1.19e-2 35/41 (85.37%) SSBP1;RAD51C;MRE11;...
RNA polymerase 1.84 1.48e-2 23/31 (74.19%) POLR2I;POLR2F;POLR2E;...
Fanconi anemia pathway 1.79 2.14e-2 36/54 (66.67%) FANCL;CENPX;RAD51C;...
Ribosome biogenesis in eukaryotes 1.79 1.78e-2 52/108 (48.15%) IMP4;GNL3;IMP3;...
Aminoacyl-tRNA biosynthesis 1.70 3.98e-2 15/66 (22.73%) IARS2;GATC;NARS2;...
Base excision repair 1.69 3.71e-2 29/33 (87.88%) POLE2;APEX1;MPG;...
T cell receptor signaling pathway -1.64 4.46e-2 93/104 (89.42%) PAK5;PAK6;BCL10;...
Longevity regulating pathway -1.64 4.57e-2 90/151 (59.6%) PRKAB1;PIK3CA;PRKACB;...
Retinol metabolism -1.64 4.64e-2 41/68 (60.29%) RDH16;ADH7;CYP26B1;...
Lipid and atherosclerosis -1.67 3.79e-2 190/215 (88.37%) RXRB;TRAF6;TLR2;...
NF-kappa B signaling pathway -1.67 3.74e-2 90/104 (86.54%) TRAF6;NFKBIA;TRAF3;...
Platelet activation -1.68 3.43e-2 106/124 (85.48%) TBXA2R;BTK;GNAI1;...
Glycine, serine and threonine metabolism -1.70 3.21e-2 31/40 (77.5%) GATM;PSAT1;PHGDH;...
Bacterial invasion of epithelial cells -1.70 3.29e-2 59/77 (76.62%) ARPC5L;PIK3CA;CDH1;...
Natural killer cell mediated cytotoxicity -1.70 3.39e-2 99/131 (75.57%) CD247;TNFSF10;BRAF;...
mRNA surveillance pathway -1.70 3.43e-2 71/98 (72.45%) PABPC3;SRRM1;TARDBP;...
Protein processing in endoplasmic reticulum -1.71 3.03e-2 127/171 (74.27%) ERP29;PPP1R15A;HSPA8;...
Inositol phosphate metabolism -1.72 3.06e-2 66/73 (90.41%) MTMR3;PLCH1;MTMR1;...
Arginine biosynthesis -1.73 2.74e-2 17/22 (77.27%) CPS1;GLUL;ASL;...
Rheumatoid arthritis -1.74 2.75e-2 78/93 (83.87%) JUN;CSF2;ATP6V0B;...
Coronavirus disease -1.74 2.84e-2 215/232 (92.67%) MAP3K7;MAPK9;RPL28;...
Cholesterol metabolism -1.74 3.03e-2 44/50 (88%) LDLRAP1;MYLIP;CETP;...
Lysosome -1.79 1.80e-2 115/128 (89.84%) MAN2B1;PPT2;LIPA;...
Chemokine signaling pathway -1.82 1.26e-2 163/192 (84.9%) IKBKB;ARRB2;CRK;...
PPAR signaling pathway -1.84 1.16e-2 66/74 (89.19%) CPT1A;CPT2;EHHADH;...
Legionellosis -1.86 5.74e-3 51/57 (89.47%) CASP9;CR1;SAR1A;...
Pertussis -1.87 6.31e-3 64/76 (84.21%) JUN;IRF8;FOS;...
Ferroptosis -1.87 7.01e-3 36/41 (87.8%) SAT1;SLC3A2;ACSL4;...
TNF signaling pathway -1.87 7.89e-3 103/112 (91.96%) NFKBIA;TRAF3;RIPK1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.88 9.02e-3 62/70 (88.57%) ATP6V1H;NFKBIA;GIT1;...
Antigen processing and presentation -1.92 1.05e-2 60/78 (76.92%) HSPA4;CALR;TAP2;...
Neutrophil extracellular trap formation -1.95 1.01e-2 101/189 (53.44%) SLC25A4;CYBB;AZU1;...
Staphylococcus aureus infection -2.01 3.16e-3 72/95 (75.79%) PLG;DEFB4A;ITGAM;...
Viral protein interaction with cytokine and cytokine re... -2.05 4.21e-3 84/100 (84%) CCL2;CCL21;LTA;...
IL-17 signaling pathway -2.10 0.00e+0 84/94 (89.36%) IFNG;MAPK6;TRAF6;...
Complement and coagulation cascades -2.60 0.00e+0 76/85 (89.41%) ITGAM;C1QA;SERPINA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H