Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM47CO1)

Drug Name
Okadaic acid Drug Info
Synonyms
78111-17-8; CHEMBL280487; CHEBI:44658; C44H68O13; 9,10-Deepithio-9,10-didehydroacanthifolicin; Ocadaic Acid; OKA; (2R)-3-[(2S,5R,6R,8S)-8-[(2R,3E)-4-[(2R,4'aR,5R,6'S,8'R,8'aS)-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-7'-methylidene-hexahydro-3'H-spiro[oxolane-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl]-5-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-hydroxy-2-methylpropanoic acid; UNII-1W21G5Q4N2; CCRIS 3329; HSDB 7243; 1W21G5Q4N2; 1jk7
Cross-matching ID
PubChem CID
446512
ChEBI ID
CHEMBL280487
CAS Number
CAS 78111-17-8
TTD Drug ID
D01SLG
VARIDT Drug ID
DR01345

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.43 0.00e+0 103/112 (91.96%) FOS;NFKBIA;JUNB;...
IL-17 signaling pathway 2.40 0.00e+0 84/94 (89.36%) FOS;FOSB;NFKBIA;...
NF-kappa B signaling pathway 2.18 0.00e+0 90/104 (86.54%) NFKBIA;GADD45B;CXCL2;...
Osteoclast differentiation 2.11 2.76e-3 117/127 (92.13%) FOS;FOSB;NFKBIA;...
Amphetamine addiction 2.09 2.21e-3 57/69 (82.61%) FOS;FOSB;JUN;...
Small cell lung cancer 1.99 5.52e-3 90/92 (97.83%) NFKBIA;GADD45B;MYC;...
TGF-beta signaling pathway 1.98 6.31e-3 81/94 (86.17%) ID2;ID1;BAMBI;...
Breast cancer 1.97 6.90e-3 119/147 (80.95%) FOS;GADD45B;HES1;...
Apoptosis 1.95 8.59e-3 126/168 (75%) FOS;NFKBIA;GADD45B;...
Fluid shear stress and atherosclerosis 1.94 8.83e-3 123/139 (88.49%) FOS;JUN;DUSP1;...
MicroRNAs in cancer 1.94 8.03e-3 146/310 (47.1%) MYC;MCL1;PIK3R3;...
Kaposi sarcoma-associated herpesvirus infection 1.93 7.36e-3 172/193 (89.12%) FOS;NFKBIA;CXCL2;...
Cocaine addiction 1.91 8.49e-3 42/49 (85.71%) FOSB;JUN;NFKB1;...
Toll-like receptor signaling pathway 1.89 1.26e-2 94/104 (90.38%) FOS;NFKBIA;JUN;...
Basal cell carcinoma 1.89 1.25e-2 41/63 (65.08%) GADD45B;FZD7;CDKN1A;...
Lipid and atherosclerosis 1.87 1.31e-2 190/215 (88.37%) FOS;NFKBIA;CXCL2;...
Colorectal cancer 1.85 1.30e-2 84/86 (97.67%) FOS;GADD45B;MYC;...
Parathyroid hormone synthesis, secretion and action 1.85 1.29e-2 98/106 (92.45%) FOS;EGR1;NR4A2;...
Hippo signaling pathway 1.83 1.51e-2 120/186 (64.52%) ID2;ID1;MYC;...
Transcriptional misregulation in cancer 1.82 1.55e-2 158/192 (82.29%) ID2;GADD45B;MYC;...
Thyroid cancer 1.81 1.61e-2 36/37 (97.3%) GADD45B;MYC;CDKN1A;...
MAPK signaling pathway 1.81 1.54e-2 272/294 (92.52%) FOS;GADD45B;NR4A1;...
Synthesis and degradation of ketone bodies 1.80 1.63e-2 9/10 (90%) HMGCS1;ACAT2;BDH2;...
C-type lectin receptor signaling pathway 1.80 1.57e-2 93/104 (89.42%) EGR3;NFKBIA;JUN;...
Viral protein interaction with cytokine and cytokine re... 1.79 1.55e-2 84/100 (84%) CXCL2;CXCR4;CXCL3;...
Legionellosis 1.79 1.50e-2 51/57 (89.47%) NFKBIA;CXCL2;CXCL3;...
Epithelial cell signaling in Helicobacter pylori infect... 1.78 1.60e-2 62/70 (88.57%) NFKBIA;CXCL2;JUN;...
Bladder cancer 1.77 1.55e-2 40/41 (97.56%) MYC;HBEGF;THBS1;...
Relaxin signaling pathway 1.76 1.60e-2 114/129 (88.37%) FOS;NFKBIA;JUN;...
Hepatitis B 1.76 1.55e-2 151/162 (93.21%) FOS;EGR3;NFKBIA;...
Pentose and glucuronate interconversions -1.74 4.38e-2 17/34 (50%) UGDH;DCXR;CRYL1;...
Folate biosynthesis -1.76 4.64e-2 23/26 (88.46%) ALPG;ALPP;PAH;...
Proteasome -1.91 8.43e-3 44/46 (95.65%) PSME2;PSMA7;PSMF1;...
Oxidative phosphorylation -2.03 0.00e+0 93/133 (69.92%) ATP6V1C1;ATP6V0B;ATP6AP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 1.11uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 1.11uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 1.11uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM 6H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM 6H