Details of the Drug Pharmacogenomic Perturbation Atlas | DrugMAP

General Information of Drug (ID: DM48F3D)

Drug Name	HU210 Drug Info
Synonyms	HU-210; HU 210; 112830-95-2; HU210; UNII-191042422P; CHEMBL307696; (-)-HU-210; 191042422P; (6aR-trans-3-(1, 1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol; GTPL731; SCHEMBL1517460; DTXSID30150188; HU-210, solid (air sensitive); ZINC2572463; PDSP2_000201; BDBM50067499; MFCD01074786; AKOS024458716; (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol; 924H455
Cross-matching ID	PubChem CID 9821569 ChEBI ID CHEMBL307696 CAS Number CAS 112830-95-2 TTD Drug ID D0F4BX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cholesterol metabolism	2.09	0.00e+0	44/50 (88%)	APOA1;APOA2;STAR;...
Ferroptosis	2.01	0.00e+0	36/41 (87.8%)	TF;SLC39A14;TFRC;...
Mineral absorption	1.98	3.91e-3	48/60 (80%)	TF;MT1F;MT1G;...
Porphyrin and chlorophyll metabolism	1.95	1.17e-2	23/43 (53.49%)	UGT2B28;PPOX;UGT2A3;...
IL-17 signaling pathway	1.91	1.17e-2	84/94 (89.36%)	FOSB;CXCL2;CXCL10;...
Complement and coagulation cascades	1.81	2.93e-2	76/85 (89.41%)	CFB;FGG;SERPINA1;...
Coronavirus disease	1.81	2.68e-2	215/232 (92.67%)	CFB;FGG;C3;...
PPAR signaling pathway	1.77	4.25e-2	66/74 (89.19%)	APOA1;APOA2;FABP1;...
NF-kappa B signaling pathway	1.76	3.91e-2	90/104 (86.54%)	RELB;CD40;CXCL2;...
Glycolysis / Gluconeogenesis	1.74	3.99e-2	56/67 (83.58%)	PGAM1;PFKL;PFKP;...
Folate biosynthesis	1.73	3.63e-2	23/26 (88.46%)	GCH1;QDPR;PAH;...
HIF-1 signaling pathway	1.73	3.32e-2	105/109 (96.33%)	TF;TFRC;PFKL;...
Protein export	1.72	3.70e-2	17/23 (73.91%)	HSPA5;SEC63;OXA1L;...
Viral protein interaction with cytokine and cytokine re...	1.72	3.60e-2	84/100 (84%)	TNFSF10;CXCL2;CXCL10;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	24H