Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4ATCI)

Drug Name
CAPSAZEPINE Drug Info
Synonyms
capsazepine; 138977-28-3; capsazepin; N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide; UNII-LFW48MY844; N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide; CHEMBL391997; LFW48MY844; ST50826300; CHEBI:70773; N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide; N-(2-[4-chlorophenyl]ethyl)-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
Cross-matching ID
PubChem CID
2733484
ChEBI ID
CHEMBL391997
CAS Number
CAS 138977-28-3
TTD Drug ID
D0G8BN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.47 0.00e+0 127/171 (74.27%) HERPUD1;HSPA6;DDIT3;...
Ferroptosis 2.34 0.00e+0 36/41 (87.8%) HMOX1;SLC7A11;GCLM;...
Amino sugar and nucleotide sugar metabolism 2.02 7.84e-3 38/48 (79.17%) UGDH;NANS;HK2;...
Antigen processing and presentation 1.94 1.18e-2 60/78 (76.92%) HSPA6;HSPA1A;HSPA8;...
Legionellosis 1.92 1.18e-2 51/57 (89.47%) HSPA6;CXCL8;HSPA1A;...
Mineral absorption 1.92 9.81e-3 48/60 (80%) HMOX1;ATP2B1;FTH1;...
Porphyrin and chlorophyll metabolism 1.91 8.40e-3 23/43 (53.49%) HMOX1;BLVRB;UGT2B28;...
IL-17 signaling pathway 1.84 2.21e-2 84/94 (89.36%) CXCL8;CEBPB;S100A9;...
Rheumatoid arthritis 1.84 1.96e-2 78/93 (83.87%) CXCL8;VEGFA;CXCL6;...
Fluid shear stress and atherosclerosis 1.80 2.71e-2 123/139 (88.49%) HMOX1;VEGFA;SQSTM1;...
One carbon pool by folate 1.76 3.32e-2 15/20 (75%) MTHFD2;SHMT2;ALDH1L1;...
HIF-1 signaling pathway 1.74 3.43e-2 105/109 (96.33%) HMOX1;VEGFA;CDKN1A;...
Glycine, serine and threonine metabolism 1.74 3.26e-2 31/40 (77.5%) CBS;PIPOX;MAOB;...
Folate biosynthesis 1.73 3.61e-2 23/26 (88.46%) GGH;AKR1C3;AKR1B10;...
PPAR signaling pathway 1.70 4.71e-2 66/74 (89.19%) HMGCS1;PCK2;PLIN2;...
Dilated cardiomyopathy -1.76 3.86e-2 86/96 (89.58%) TPM3;ITGA8;LAMA2;...
Oxidative phosphorylation -1.77 4.42e-2 93/133 (69.92%) COX6A2;ATP4B;COX4I1;...
Oocyte meiosis -1.87 1.07e-2 90/129 (69.77%) YWHAH;STAG3;ANAPC13;...
Cell cycle -1.95 1.21e-2 110/124 (88.71%) CDC6;YWHAH;ANAPC13;...
DNA replication -2.02 8.04e-3 34/36 (94.44%) POLE3;RPA2;POLA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12.5uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H