Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4BACH)

Drug Name
Kifunensine Drug Info
Synonyms
kifunensine; 109944-15-2; UNII-0NI8960271; Kifunensine, Kitasatosporia kifunense; (5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)hexahydroimidazo[1,2-a]pyridine-2,3-dione; FR 900494; 0NI8960271; KIF; C8H12N2O6; Imidazo(1,2-a)pyridine-2,3-dione, hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5R-(5alpha,6beta,7alpha,8alpha,8aalpha))-; (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
Cross-matching ID
PubChem CID
130611
CAS Number
CAS 109944-15-2
TTD Drug ID
D0AD9Y

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Leishmaniasis 1.95 2.08e-2 67/77 (87.01%) HLA-DQA1;FCGR2A;FCGR2C;...
Protein processing in endoplasmic reticulum 1.95 1.04e-2 127/171 (74.27%) GANAB;MAP3K5;HYOU1;...
Antigen processing and presentation 1.92 6.95e-3 60/78 (76.92%) HLA-DQA1;CD74;CTSS;...
Glycolysis / Gluconeogenesis 1.90 5.21e-3 56/67 (83.58%) FBP1;PGAM1;HK2;...
Protein export 1.89 6.25e-3 17/23 (73.91%) SRPRA;SEC61A1;SPCS3;...
Herpes simplex virus 1 infection 1.73 4.69e-2 165/498 (33.13%) HLA-DQA1;OAS2;OAS1;...
Phagosome 1.72 4.47e-2 118/152 (77.63%) HLA-DQA1;FCGR2A;FCGR2C;...
Tryptophan metabolism -1.72 4.92e-2 35/42 (83.33%) DHTKD1;DDC;DLD;...
Folate biosynthesis -1.83 3.05e-2 23/26 (88.46%) MOCS2;QDPR;AKR1B1;...
Steroid hormone biosynthesis -1.89 1.93e-2 43/61 (70.49%) HSD17B7;CYP2E1;AKR1C4;...
Glutathione metabolism -1.92 1.93e-2 43/57 (75.44%) ANPEP;GPX3;SMS;...
Metabolism of xenobiotics by cytochrome P450 -2.04 6.42e-3 49/77 (63.64%) AKR7A3;CBR3;ALDH3B1;...
Steroid biosynthesis -2.07 9.63e-3 19/20 (95%) LIPA;NSDHL;HSD17B7;...
Mineral absorption -2.26 0.00e+0 48/60 (80%) FTL;ATP2B4;ATP2B2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H