Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4CDIB)

Drug Name
L-655708 Drug Info
Synonyms
130477-52-0; CHEMBL52030; NCGC00025115-02; Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate; Lopac0_000700; SCHEMBL5533646; YKYOQIXTECBVBB-AWEZNQCLSA-N; MolPort-003-983-605; HMS3262K21; ZINC2584032; Tox21_500700; MFCD02684528; BN0287; BDBM50067424; AKOS024456530; FG-8094; API0007742; LP00700; CCG-204785; CS-4943; NCGC00261385-01; NCGC00025115-04; NCGC00025115-03; HY-14426; KB-78047; EU-0100700; L-655,708, &gt
Cross-matching ID
PubChem CID
5311203
ChEBI ID
CHEMBL52030
TTD Drug ID
D0O9MG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Intestinal immune network for IgA production 2.40 0.00e+0 38/48 (79.17%) HLA-DMB;HLA-DPB1;HLA-DQB1;...
Oxidative phosphorylation 2.04 0.00e+0 93/133 (69.92%) ATP6V0E2;COX7B;ATP5MC3;...
Asthma 2.02 0.00e+0 25/31 (80.65%) HLA-DMB;HLA-DPB1;FCER1A;...
Mismatch repair 1.94 0.00e+0 22/23 (95.65%) RPA3;PCNA;MSH2;...
Systemic lupus erythematosus 1.93 0.00e+0 45/135 (33.33%) HLA-DMB;C7;HLA-DPB1;...
Staphylococcus aureus infection 1.91 3.67e-3 72/95 (75.79%) KRT17;KRT19;HLA-DMB;...
DNA replication 1.77 2.36e-2 34/36 (94.44%) DNA2;POLE2;RPA3;...
Inflammatory bowel disease 1.71 4.12e-2 58/65 (89.23%) TLR4;HLA-DMB;HLA-DPB1;...
Leishmaniasis 1.71 4.03e-2 67/77 (87.01%) TLR4;CYBB;PRKCB;...
Homologous recombination 1.70 3.63e-2 35/41 (85.37%) RAD54B;RAD51C;RPA3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H