Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4DG1Y)

Drug Name
naringin Drug Info
Synonyms Naringoside; AC1NR4U8; 4',5,7-Trihydroxyflavanone-7-rutinoside; 4',5,7-Trihydroxyflavanone-7-rhamnoglucoside
Cross-matching ID
PubChem CID
442428
ChEBI ID
CHEMBL451532
CAS Number
CAS 10236-47-2
TTD Drug ID
D09VQM
VARIDT Drug ID
DR00581

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycosaminoglycan degradation -1.72 4.39e-2 19/19 (100%) HGSNAT;HEXB;HYAL2;...
Morphine addiction -1.79 2.25e-2 80/91 (87.91%) GABRD;PRKCA;GNG4;...
Protein processing in endoplasmic reticulum -1.81 1.89e-2 127/171 (74.27%) DNAJC1;SSR4;DNAJB12;...
Steroid hormone biosynthesis -1.85 1.35e-2 43/61 (70.49%) HSD17B6;CYP1A2;CYP11B2;...
Biosynthesis of unsaturated fatty acids -1.89 9.01e-3 21/27 (77.78%) ELOVL4;BAAT;HACD3;...
Neutrophil extracellular trap formation -1.93 6.76e-3 101/189 (53.44%) HDAC4;PLCG1;MAPK3;...
Nicotine addiction -1.99 1.35e-2 32/40 (80%) GABRR2;GRIN2C;GABRA4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H