Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4DOUB)

Drug Name
PMID28460551-Compound-2 Drug Info
Cross-matching ID
PubChem CID
5329102
ChEBI ID
CHEMBL535
CAS Number
CAS 557795-19-4
TTD Drug ID
D0YX2B
ACDINA Drug ID
D00646

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.49 0.00e+0 19/20 (95%) MSMO1;DHCR24;SQLE;...
Cysteine and methionine metabolism 2.33 0.00e+0 43/50 (86%) PSAT1;PHGDH;CBS;...
Valine, leucine and isoleucine degradation 2.31 0.00e+0 42/48 (87.5%) HMGCS1;ACAT2;ALDH6A1;...
Glycine, serine and threonine metabolism 2.28 0.00e+0 31/40 (77.5%) PSAT1;PHGDH;CBS;...
Arginine biosynthesis 2.25 0.00e+0 17/22 (77.27%) ASS1;GOT1;ARG2;...
Terpenoid backbone biosynthesis 2.22 0.00e+0 18/22 (81.82%) HMGCS1;ACAT2;IDI1;...
Alanine, aspartate and glutamate metabolism 2.19 1.54e-3 27/37 (72.97%) ASNS;ASS1;GOT1;...
Fatty acid degradation 2.16 1.35e-3 40/43 (93.02%) ACAT2;ALDH2;ACSL1;...
Biosynthesis of unsaturated fatty acids 2.13 1.20e-3 21/27 (77.78%) SCD;FADS1;FADS2;...
Selenocompound metabolism 2.05 1.08e-3 11/17 (64.71%) CTH;TXNRD1;SEPHS2;...
Glyoxylate and dicarboxylate metabolism 2.04 9.79e-4 23/30 (76.67%) ACAT2;SHMT2;ACAT1;...
Proximal tubule bicarbonate reclamation 1.98 8.97e-4 21/23 (91.3%) PCK2;SLC4A4;FXYD2;...
Pyruvate metabolism 1.98 8.28e-4 41/47 (87.23%) PCK2;ACAT2;ALDH2;...
Butanoate metabolism 1.97 7.69e-4 23/28 (82.14%) HMGCS1;ACAT2;ALDH5A1;...
beta-Alanine metabolism 1.96 1.44e-3 25/30 (83.33%) ALDH6A1;ALDH2;AOC3;...
Pantothenate and CoA biosynthesis 1.96 1.35e-3 14/21 (66.67%) ALDH2;PANK3;ALDH1B1;...
Synthesis and degradation of ketone bodies 1.94 1.27e-3 9/10 (90%) HMGCS1;ACAT2;ACAT1;...
Riboflavin metabolism 1.93 1.20e-3 7/8 (87.5%) BLVRB;RFK
PPAR signaling pathway 1.92 1.70e-3 66/74 (89.19%) SCD;PCK2;HMGCS1;...
Tryptophan metabolism 1.89 1.62e-3 35/42 (83.33%) ACAT2;ALDH2;MAOA;...
Pentose phosphate pathway 1.86 4.10e-3 25/30 (83.33%) PGD;ALDOB;TKT;...
Fatty acid biosynthesis 1.84 4.89e-3 16/18 (88.89%) ACSL1;ACACA;FASN;...
Phenylalanine metabolism 1.84 4.68e-3 14/17 (82.35%) GOT1;MAOA;AOC3;...
AMPK signaling pathway 1.84 4.49e-3 106/120 (88.33%) SCD;PCK2;EIF4EBP1;...
Oxidative phosphorylation 1.82 4.31e-3 93/133 (69.92%) NDUFB1;NDUFA4;COX7A1;...
Citrate cycle (TCA cycle) 1.79 7.87e-3 30/30 (100%) PCK2;IDH1;ACO2;...
Propanoate metabolism 1.78 9.17e-3 30/34 (88.24%) ACAT2;ALDH6A1;ACACA;...
One carbon pool by folate 1.77 8.85e-3 15/20 (75%) MTHFD2;SHMT2;ALDH1L1;...
Insulin resistance 1.76 1.04e-2 96/108 (88.89%) PCK2;TRIB3;IRS2;...
Insulin signaling pathway 1.75 1.22e-2 121/137 (88.32%) PCK2;EIF4EBP1;IRS2;...
Pertussis -1.86 5.47e-3 64/76 (84.21%) C1S;IL12A;TLR4;...
IL-17 signaling pathway -1.94 2.28e-3 84/94 (89.36%) MAPK6;S100A7;GSK3B;...
Legionellosis -1.98 3.04e-3 51/57 (89.47%) CASP9;MYD88;CXCL3;...
Cell cycle -2.08 4.56e-3 110/124 (88.71%) GADD45B;RAD21;HDAC2;...
DNA replication -2.16 0.00e+0 34/36 (94.44%) POLE3;DNA2;RFC4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H