Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4E8O9)

Drug Name
Umeclidinium Drug Info
Synonyms 573719
Cross-matching ID
PubChem CID
11519070
ChEBI ID
CHEMBL79041
CAS Number
CAS 869185-19-3
TTD Drug ID
D00SLY
VARIDT Drug ID
DR00012
ACDINA Drug ID
D01512

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Histidine metabolism -1.61 4.15e-2 16/22 (72.73%) ALDH7A1;ASPA;ALDH1B1;...
Gastric acid secretion -1.62 4.23e-2 63/76 (82.89%) ADCY8;ATP1A2;CAMK2G;...
alpha-Linolenic acid metabolism -1.62 4.06e-2 17/25 (68%) PLA2G10;PLA2G2A;ACOX1;...
Legionellosis -1.65 3.52e-2 51/57 (89.47%) HSPA6;BCL2L13;HSPA1A;...
Nitrogen metabolism -1.65 3.47e-2 16/17 (94.12%) CA5A;CPS1;GLUD2;...
Ovarian steroidogenesis -1.66 3.33e-2 41/51 (80.39%) CGA;ADCY8;STAR;...
Oxidative phosphorylation -1.67 3.43e-2 93/133 (69.92%) ATP6V0D1;ATP6V0B;ATP5MC1;...
Peroxisome -1.67 3.54e-2 72/82 (87.8%) PECR;IDH2;PEX19;...
Phenylalanine metabolism -1.68 3.25e-2 14/17 (82.35%) TAT;MAOA;GOT2;...
Synaptic vesicle cycle -1.68 3.18e-2 63/78 (80.77%) ATP6V0D1;ATP6V0B;SLC6A9;...
Ascorbate and aldarate metabolism -1.74 1.86e-2 15/30 (50%) RGN;ALDH7A1;ALDH1B1;...
Selenocompound metabolism -1.75 1.91e-2 11/17 (64.71%) SEPHS2;PAPSS2
Butanoate metabolism -1.76 1.85e-2 23/28 (82.14%) AACS;HMGCL;BDH2;...
Ferroptosis -1.78 1.27e-2 36/41 (87.8%) ACSL4;ATG5;GCLM;...
Collecting duct acid secretion -1.78 1.23e-2 22/27 (81.48%) ATP6V0A2;ATP6V1E1;ATP6V1C1;...
Synthesis and degradation of ketone bodies -1.81 8.50e-3 9/10 (90%) HMGCL;BDH2;ACAT2;...
PPAR signaling pathway -1.82 7.70e-3 66/74 (89.19%) ACSL1;EHHADH;ILK;...
Arginine biosynthesis -1.87 3.02e-3 17/22 (77.27%) GPT;GOT2;CPS1;...
Regulation of lipolysis in adipocytes -1.88 2.45e-3 52/55 (94.55%) PRKACB;NPY1R;IRS1;...
Metabolism of xenobiotics by cytochrome P450 -1.89 2.67e-3 49/77 (63.64%) CYP1A1;GSTA1;CYP3A5;...
Valine, leucine and isoleucine degradation -1.89 2.94e-3 42/48 (87.5%) AACS;HMGCL;ACADSB;...
Mineral absorption -1.92 2.18e-3 48/60 (80%) HMOX2;SLC26A3;ATP1B3;...
Proximal tubule bicarbonate reclamation -1.95 1.23e-3 21/23 (91.3%) PCK2;MDH1;ATP1A2;...
Steroid hormone biosynthesis -1.96 1.40e-3 43/61 (70.49%) HSD3B1;CYP1A1;CYP3A5;...
Retinol metabolism -1.98 0.00e+0 41/68 (60.29%) CYP2C18;HSD17B6;RDH16;...
Complement and coagulation cascades -2.03 0.00e+0 76/85 (89.41%) KNG1;MASP1;C8B;...
Bile secretion -2.04 0.00e+0 68/90 (75.56%) ABCB1;ADCY8;ATP1A2;...
Fatty acid degradation -2.05 0.00e+0 40/43 (93.02%) HADH;HADHB;ADH1B;...
Porphyrin and chlorophyll metabolism -2.07 0.00e+0 23/43 (53.49%) ALAS2;BLVRA;HMOX2;...
Linoleic acid metabolism -2.09 0.00e+0 21/29 (72.41%) CYP2C9;CYP2E1;CYP2J2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H