Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4ES8F)

• Drug Name: Penbutolol Drug Info
• Synonyms: Betapressin; Levatol; Levatolol; Levopenbutol; Lobeta; Paginol; Penbutololum; PENBUTOLOL SULFATE; HOE 893; HOE 893d; Betapressin (TN); Hostabloc (TN); L-Penbutolol; Levatol (TN); Levatolol (TN); Lobeta (TN); Paginol (TN); Penbutolol (INN); Penbutolol [INN:BAN]; Penbutololum [INN-Latin]; Penbutolol Sulfate (2:1); S(-)-Penbutolol; (-)-Penbutolol; (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol; 1-(tert-Butylamino)-3-(o-cyclopentylphenoxy)propan-2-ol
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 37464
  ChEBI ID: CHEMBL7954
  CAS Number: CAS 38363-40-5
  TTD Drug ID: D0W8SB
  INTEDE Drug ID: DR1249
  ACDINA Drug ID: D00513

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	-1.79	4.28e-2	34/36 (94.44%)	RPA1;MCM2;RFC5;...
Homologous recombination	-1.81	4.28e-2	35/41 (85.37%)	BLM;BABAM2;RPA2;...
One carbon pool by folate	-1.89	3.21e-2	15/20 (75%)	TYMS;MTHFD1;SHMT2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲