Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4FW3H)

Drug Name
ETICLOPRIDE Drug Info
Synonyms
Eticlopride; Eticlopride [INN]; Eticlopridum [Latin]; Eticloprida [Spanish]; CHEMBL8946; UNII-J8M468HBH4; J8M468HBH4; FLB 131; FLB-131; 3-Chloro-5-Ethyl-N-{[(2s)-1-Ethylpyrrolidin-2-Yl]methyl}-6-Hydroxy-2-Methoxybenzamide; C17H25ClN2O3; 5-chloro-3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide; (-)-(S)-5-Chloro-3-ethyl-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-methoxysalicylamide; NCGC00016963-01; NCGC00161393-01; CAS-97612-24-3; Eticlopridum; Eticloprida; Prestwick3_000932; ETICLOPRIDE,S(-); AC1L1MN4
Cross-matching ID
PubChem CID
57267
ChEBI ID
CHEMBL8946
CAS Number
CAS 84226-12-0
TTD Drug ID
D03KUH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 1.93 4.41e-2 80/88 (90.91%) COL9A2;COMP;THBS4;...
Porphyrin and chlorophyll metabolism -1.73 4.58e-2 23/43 (53.49%) HCCS;COX15;UGT2B28;...
Sulfur metabolism -1.75 4.09e-2 9/10 (90%) SQOR;PAPSS2;ETHE1
Proteasome -1.77 3.25e-2 44/46 (95.65%) POMP;PSMA3;PSMB1;...
Protein processing in endoplasmic reticulum -1.81 1.60e-2 127/171 (74.27%) PDIA3;SEC61G;FBXO2;...
Steroid hormone biosynthesis -1.98 0.00e+0 43/61 (70.49%) COMT;CYP3A5;HSD17B6;...
Ferroptosis -2.02 0.00e+0 36/41 (87.8%) LPCAT3;PCBP1;ATG5;...
Mineral absorption -2.05 0.00e+0 48/60 (80%) MT1M;TF;ATP2B2;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -2.06 0.00e+0 20/26 (76.92%) PIGN;PIGA;PIGH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H