Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4G8WX)

• Drug Name: Pyridine-2,4-dicarboxylic acid Drug Info
• Synonyms: Pyridine-2,4-dicarboxylic acid; 499-80-9; 2,4-PYRIDINEDICARBOXYLIC ACID; Lutidinic acid; 2,4-Lutidinic acid; UNII-AFI29F0TVL; AFI29F0TVL; CHEBI:44737; EC 207-892-2; MJIVRKPEXXHNJT-UHFFFAOYSA-N; MFCD00149413; 2,4-Pyridinedicarboxylic acid hydrate, 99+%; 2,4-Pyridinedicarboxylicacid, hydrate (1:1); 4nrq; PD2; EINECS 207-892-2; NSC 403248; PubChem16314; 4-carboxypicolinic acid; 2vd7; 4ie0; 2w2i; pyridine carboxylate, 6a; AC1Q5UFW; ACMC-1BNB9; AC1L1V1N; 2,4-Pyridine-dicarboxylate; SCHEMBL72377; cid_10365; MLS000078055; GTPL8744
• Cross-matching ID:
  PubChem CID: 10365
  ChEBI ID: CHEMBL316034
  CAS Number: CAS 499-80-9
  TTD Drug ID: D07IOY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Intestinal immune network for IgA production	2.11	0.00e+0	38/48 (79.17%)	CXCL12;IL15;HLA-DOB;...
Porphyrin and chlorophyll metabolism	1.99	1.15e-2	23/43 (53.49%)	CP;UGT2B28;COX15;...
Viral protein interaction with cytokine and cytokine re...	1.99	7.65e-3	84/100 (84%)	CXCL12;TNFSF10;CX3CR1;...
Primary immunodeficiency	1.86	2.58e-2	33/38 (86.84%)	ADA;CD8A;CD3E;...
beta-Alanine metabolism	1.80	2.76e-2	25/30 (83.33%)	ALDH6A1;ABAT;CNDP2;...
African trypanosomiasis	1.80	2.30e-2	32/37 (86.49%)	HBB;PRKCB;F2RL1;...
Morphine addiction	1.79	2.30e-2	80/91 (87.91%)	PRKCB;PDE1A;GNG11;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲