Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4I07A)

• Drug Name: Iopamidol Drug Info
• Synonyms: Iopamiro; Iopamiron; Isovue; Niopam
• Cross-matching ID:
  PubChem CID: 65492
  ChEBI ID: CHEMBL31711
  CAS Number: CAS 60166-93-0
  TTD Drug ID: D0O2HQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Retinol metabolism	2.26	0.00e+0	41/68 (60.29%)	CYP1A1;UGT2B17;DHRS9;...
Mineral absorption	1.98	1.31e-2	48/60 (80%)	MT1E;MT1G;MT1H;...
Pantothenate and CoA biosynthesis	-1.73	4.73e-2	14/21 (66.67%)	ALDH2;COASY;AASDHPPT;...
Staphylococcus aureus infection	-1.76	3.32e-2	72/95 (75.79%)	FPR1;HLA-DOB;SELP;...
Intestinal immune network for IgA production	-1.80	2.21e-2	38/48 (79.17%)	IL6;ICOS;CD86;...
Th1 and Th2 cell differentiation	-1.82	1.66e-2	80/92 (86.96%)	MAF;MAPK3;NFKBIE;...
Leishmaniasis	-1.82	1.90e-2	67/77 (87.01%)	MAPK3;IRAK4;NFKBIA;...
Viral myocarditis	-1.83	1.48e-2	53/60 (88.33%)	CXADR;SGCA;MYH7;...
Cell adhesion molecules	-1.89	8.86e-3	118/148 (79.73%)	ITGAM;CLDN5;CD4;...
Type I diabetes mellitus	-2.02	0.00e+0	38/43 (88.37%)	CD86;HLA-E;HLA-DOB;...
Allograft rejection	-2.05	0.00e+0	32/38 (84.21%)	CD86;CD40LG;HLA-E;...
Graft-versus-host disease	-2.07	0.00e+0	32/42 (76.19%)	IL6;CD86;HLA-E;...
Autoimmune thyroid disease	-2.13	0.00e+0	46/53 (86.79%)	CD86;CD40LG;HLA-E;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲