Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4KCYU)

• Drug Name: [3H]8-OH-DPAT Drug Info
• Synonyms: 8-OH-Dpat; 78950-78-4; 8-HYDROXY-2-(DI-n-PROPYLAMINO)TETRALIN; 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; 8-Hydroxy-DPAT; CHEMBL56; Ro-31-8220 in solution; CHEBI:73364; 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-; S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT; (+/-)-8-HYDROXY-2-DIPROPYL-AMINOTETRALIN; [3H]-8-OH-DPAT; (+/-)-8-Hydroxy-DPAT hydrobromide; [3H]8-OH-DPAT; (+-)-8-OH-DPAT; S(-)-8-OH-DPAT HBr; S(-)-8-Hydroxy-DPAT hydrobromide; dl-8-Hydroxy-2-(dipropylamino)tetralin; GTPL7; 8OH-DPAT
• Cross-matching ID:
  PubChem CID: 1220
  ChEBI ID: CHEMBL56
  CAS Number: CAS 78950-78-4
  TTD Drug ID: D0O3GF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	1.97	1.20e-2	48/60 (80%)	SLC30A1;MT1M;CYBRD1;...
Glyoxylate and dicarboxylate metabolism	1.86	3.60e-2	23/30 (76.67%)	GLUL;DLD;PCCA;...
Nitrogen metabolism	1.85	3.60e-2	16/17 (94.12%)	CA2;GLUL;GLUD2;...
TGF-beta signaling pathway	1.82	4.20e-2	81/94 (86.17%)	ID1;BMP4;RHOA;...
Primary immunodeficiency	-1.91	3.71e-2	33/38 (86.84%)	TAP1;CD8B;RAG2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Bone marrow

Neuroblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SH-SY5Y	CVCL_0019	Homo sapiens	0.04uM - 10uM	24H	Hide ▲
SK-N-SH	CVCL_0531	Homo sapiens	0.04uM - 10uM	24H	Show ▼