Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4KLPT)

Drug Name
Terfenadine Drug Info
Synonyms
Aldaban; Allerplus; Cyater; Hisfedin; Rapidal; Seldane; Teldane; Teldanex; Terdin; Terfedura; Terfemundin; Terfen; Terfenadina; Terfenadinum; Terfenidine; Terfex; Ternadin; Triludan; Aliud Brand of Terfenadine; Balkis Saft Spezial; Bial Brand of Terfenadine; Cantabria Brand of Terfenadine; Ct Arzneimittel Brand of Terfenadine; Dolorgiet Brand of Terfenadine; Heumann Brand of Terfenadine; Hoechst Brand of Terfenadine; Merck dura Brand of Terfenadine; Mundipharma Brand of Terfenadine; Ratiopharm Brand of Terfenadine; Sigma Tau Brand of Terfenadine; Stadapharm Brand of Terfenadine; Terfenadin AL; Terfenadin Heumann; Terfenadin Stada; Terfenadin von ct; Wolff Brand of Terfenadine; MDL 9918; RMI 9918; RMI9918; T 9652; Ct-Arzneimittel Brand of Terfenadine; MDL-9918; RMI-9918; Seldane (TN); Sigma-Tau Brand of Terfenadine; Teldane (TN); Terfenadin-ratiopharm; Terfenadina [INN-Spanish]; Terfenadinum [INN-Latin]; Triludan (TN); Terfenadine (JAN/USAN/INN); Terfenadine [USAN:BAN:INN:JAN]; Alpha-(4-[1,1-Dimethylethyl]phenyl)-4-[hydroxydiphenylmethyl]-1-piperidinebutanol; Alpha-(p-tert-Butylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol; Alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenyl-methyl)-1-piperidine butanol; 1-(4-tert-Butylphenyl)-4-(4-(alpha-hydroxybenzhydryl)piperidino)-butan-1-ol; 1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol; 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol; 1-(p-tert-Butylphenyl)-4-(4'-(alpha-hydroxydiphenylmethyl)-1'-piperidyl)butanol; 1-[4-(1,1-dimethylethyl)phenyl]-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butan-1-ol
Therapeutic ClassAntihistamines
Cross-matching ID
PubChem CID
5405
ChEBI ID
CHEMBL17157
CAS Number
CAS 50679-08-8
TTD Drug ID
D08SOF
VARIDT Drug ID
DR00755
INTEDE Drug ID
DR1558

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.45 0.00e+0 19/20 (95%) MSMO1;DHCR7;SQLE;...
PPAR signaling pathway 2.31 0.00e+0 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Biosynthesis of unsaturated fatty acids 2.10 0.00e+0 21/27 (77.78%) SCD;FADS1;FADS2;...
Ferroptosis 2.06 0.00e+0 36/41 (87.8%) HMOX1;SLC7A11;ACSL3;...
Terpenoid backbone biosynthesis 1.99 2.37e-3 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Steroid hormone biosynthesis 1.92 7.90e-3 43/61 (70.49%) AKR1C3;CYP1B1;AKR1C2;...
Ovarian steroidogenesis 1.92 6.77e-3 41/51 (80.39%) AKR1C3;CYP1B1;LDLR;...
Amino sugar and nucleotide sugar metabolism 1.92 5.93e-3 38/48 (79.17%) UGDH;AMDHD2;GNE;...
Mitophagy 1.89 5.27e-3 56/68 (82.35%) ATF4;SQSTM1;FOXO3;...
Porphyrin and chlorophyll metabolism 1.86 1.07e-2 23/43 (53.49%) HMOX1;UGT2B4;UGT2B28;...
Insulin resistance 1.81 2.48e-2 96/108 (88.89%) TRIB3;PCK2;CD36;...
mTOR signaling pathway 1.80 2.86e-2 114/154 (74.03%) DDIT4;LPIN1;SLC3A2;...
AMPK signaling pathway 1.77 3.47e-2 106/120 (88.33%) SCD;FASN;HMGCR;...
Complement and coagulation cascades 1.77 3.22e-2 76/85 (89.41%) CFB;F5;SERPINA1;...
Protein processing in endoplasmic reticulum 1.75 3.48e-2 127/171 (74.27%) HERPUD1;DDIT3;HSPA6;...
Fluid shear stress and atherosclerosis 1.73 4.00e-2 123/139 (88.49%) HMOX1;VEGFA;ARHGEF2;...
Type II diabetes mellitus 1.72 4.11e-2 42/46 (91.3%) ADIPOQ;INSR;PKM;...
Cholesterol metabolism 1.70 4.74e-2 44/50 (88%) LDLR;NPC1;CD36;...
Cell cycle -1.75 2.05e-2 110/124 (88.71%) MCM7;ANAPC5;SKP1;...
Base excision repair -1.79 1.54e-2 29/33 (87.88%) PARP1;HMGB1;PCNA;...
RNA transport -1.79 1.65e-2 128/186 (68.82%) EIF3B;RPP30;SENP2;...
Proteasome -1.88 8.97e-3 44/46 (95.65%) PSMA7;PSMB5;PSMA5;...
Mismatch repair -1.91 7.69e-3 22/23 (95.65%) RFC2;EXO1;POLD1;...
Spliceosome -1.94 1.92e-3 101/150 (67.33%) SNRPD3;LSM2;CRNKL1;...
Ribosome biogenesis in eukaryotes -2.02 2.56e-3 52/108 (48.15%) RPP30;REXO2;NXF1;...
RNA polymerase -2.05 0.00e+0 23/31 (74.19%) POLR2A;POLR2B;POLR2G;...
DNA replication -2.23 0.00e+0 34/36 (94.44%) MCM3;POLA1;RFC2;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 4uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 6.66uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H