Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4LNBQ)

Drug Name
Pyroxamide Drug Info
Synonyms
POLAR HYBRID COMPOUND; Suberoyl-3-aminopyridineamide hydroxamic acid; N-Hydroxy-N'-3-pyridinyloctanediamide; N'-hydroxy-N-pyridin-3-yloctanediamide; N-hydroxy-n'-(pyridin-3-yl)octanediamide; N-Hydroxy-N'-(3-pyridyl)-1,8-octanediamide
Cross-matching ID
PubChem CID
4996
ChEBI ID
CHEMBL353581
CAS Number
CAS 382180-17-8
TTD Drug ID
D0N3SH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Bacterial invasion of epithelial cells 2.14 0.00e+0 59/77 (76.62%) FN1;ITGA5;CLTB;...
Regulation of lipolysis in adipocytes 2.03 0.00e+0 52/55 (94.55%) PRKACB;NPY1R;GNAI1;...
Cholinergic synapse 1.97 0.00e+0 99/113 (87.61%) FYN;PRKCA;PRKACB;...
Aldosterone-regulated sodium reabsorption 1.95 9.48e-3 34/37 (91.89%) PRKCA;SCNN1A;ATP1B1;...
Dopaminergic synapse 1.90 1.01e-2 115/132 (87.12%) KIF5C;PRKCA;PRKACB;...
Adherens junction 1.88 1.26e-2 63/71 (88.73%) FYN;IGF1R;NECTIN3;...
Synaptic vesicle cycle 1.84 1.62e-2 63/78 (80.77%) SLC1A1;STXBP1;ATP6V0B;...
Vibrio cholerae infection 1.81 1.74e-2 44/50 (88%) PRKCA;PRKACB;ATP6V0B;...
Adrenergic signaling in cardiomyocytes 1.81 1.68e-2 130/150 (86.67%) PRKCA;PRKACB;ATP1B1;...
Steroid biosynthesis 1.81 1.52e-2 19/20 (95%) LIPA;MSMO1;TM7SF2;...
Retinol metabolism 1.80 1.61e-2 41/68 (60.29%) ALDH1A2;AOX1;ADH1B;...
Glutamatergic synapse 1.80 1.58e-2 97/114 (85.09%) SLC1A1;PRKCA;PRKACB;...
Leukocyte transendothelial migration 1.78 1.46e-2 90/114 (78.95%) PRKCA;EZR;GNAI1;...
Renin-angiotensin system 1.78 1.44e-2 20/23 (86.96%) CPA3;AGT;MME;...
Tight junction 1.77 1.35e-2 130/169 (76.92%) PRKACB;PRKAG2;MYH10;...
Gap junction 1.76 1.42e-2 72/88 (81.82%) PRKCA;PRKACB;GNAI1;...
Serotonergic synapse 1.73 1.78e-2 97/114 (85.09%) PRKCA;PRKACB;GNAI1;...
Gastric acid secretion 1.73 1.68e-2 63/76 (82.89%) PRKCA;PRKACB;ATP1B1;...
Hematopoietic cell lineage 1.72 1.60e-2 90/99 (90.91%) CD55;CD1E;CR2;...
Endocrine and other factor-regulated calcium reabsorpti... 1.72 1.64e-2 49/53 (92.45%) PRKCA;PRKACB;ATP1B1;...
Morphine addiction 1.72 1.56e-2 80/91 (87.91%) PRKCA;PRKACB;GRK5;...
Circadian entrainment 1.72 1.55e-2 85/97 (87.63%) PRKCA;PRKACB;GNAI1;...
Apelin signaling pathway 1.69 1.87e-2 117/137 (85.4%) PRKACB;PRKAG2;GNAI1;...
Vasopressin-regulated water reabsorption 1.69 2.16e-2 40/44 (90.91%) PRKACB;CREB3L2;AQP3;...
Dilated cardiomyopathy 1.68 2.27e-2 86/96 (89.58%) PRKACB;AGT;PLN;...
Amphetamine addiction 1.68 2.28e-2 57/69 (82.61%) PRKCA;PRKACB;CREB3L2;...
Yersinia infection 1.68 2.20e-2 120/137 (87.59%) FYB1;FN1;RPS6KA3;...
Inflammatory mediator regulation of TRP channels 1.67 2.44e-2 82/98 (83.67%) PRKCA;PRKACB;PTGER2;...
Melanogenesis 1.65 2.49e-2 74/101 (73.27%) PRKCA;PRKACB;CREB3L2;...
Lysosome 1.65 2.49e-2 115/128 (89.84%) LIPA;PLA2G15;ATP6V0B;...
Cysteine and methionine metabolism -1.70 4.66e-2 43/50 (86%) BCAT1;AHCYL2;GCLC;...
Spliceosome -2.03 7.17e-3 101/150 (67.33%) CDC5L;ACIN1;RBMX;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.66uM - 10uM 6H, 24H