Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4LSPN)

Drug Name
Ibudilast Drug Info
Synonyms
Eyevinal; Ibudilastum; Ketas; Ibudilastum [Latin]; Ke Tas; AV 411; I 0157; KC 404; AV-411; Ibudilast [INN:JAN]; KC-404; Ketas (TN); MN-166; Ibudilast (JAN/INN); 1-(2-Isopropylpyrazolo(1,5-a)pyridin-3-yl)-2-methyl-1-propanone; 2-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridine; 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone; 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one; 3-Isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine; 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
Cross-matching ID
PubChem CID
3671
ChEBI ID
CHEMBL31684
CAS Number
CAS 50847-11-5
TTD Drug ID
D03QJL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nitrogen metabolism 2.13 0.00e+0 16/17 (94.12%) CA2;GLUL;GLUD2;...
Oxidative phosphorylation 2.09 0.00e+0 93/133 (69.92%) ATP5PF;ATP5F1C;NDUFS3;...
DNA replication 2.06 0.00e+0 34/36 (94.44%) MCM5;RFC2;RPA3;...
Ribosome 2.04 0.00e+0 113/158 (71.52%) RPS25;RPL29;RPL15;...
Proximal tubule bicarbonate reclamation 1.91 1.09e-2 21/23 (91.3%) CA2;SLC4A4;AQP1;...
Mismatch repair 1.84 2.13e-2 22/23 (95.65%) MSH2;RFC2;RPA3;...
Parkinson disease 1.83 1.95e-2 176/249 (70.68%) DAXX;ATP5PF;CYCS;...
Cardiac muscle contraction 1.74 3.53e-2 64/87 (73.56%) TPM2;ATP2A1;TNNC1;...
Alanine, aspartate and glutamate metabolism 1.72 3.75e-2 27/37 (72.97%) ASRGL1;GLUL;GAD1;...
Nucleotide excision repair 1.69 4.47e-2 40/47 (85.11%) RFC2;RAD23B;RBX1;...
Diabetic cardiomyopathy 1.68 4.73e-2 162/203 (79.8%) GAPDH;TGFBR2;AGTR1;...
Steroid biosynthesis -1.85 3.61e-2 19/20 (95%) NSDHL;MSMO1;LSS;...
Regulation of lipolysis in adipocytes -2.04 0.00e+0 52/55 (94.55%) PTGS2;INSR;PIK3CD;...
Cholesterol metabolism -2.31 0.00e+0 44/50 (88%) LRPAP1;ANGPTL8;NPC2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 15uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H