Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4MF9V)

Drug Name
proglumide Drug Info
Synonyms Milid; Nulsa; W-5219
Cross-matching ID
PubChem CID
4922
ChEBI ID
CHEMBL316561
CAS Number
CAS 6620-60-6
TTD Drug ID
D04HQT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Peroxisome -1.69 3.84e-2 72/82 (87.8%) MPV17;SOD1;AGXT;...
Prion disease -1.74 2.16e-2 209/273 (76.56%) PSMB6;RYR2;NDUFA9;...
Ribosome -1.77 1.96e-2 113/158 (71.52%) RPL10L;MRPL20;RPL41;...
Parkinson disease -1.84 9.82e-3 176/249 (70.68%) PSMB6;NDUFA9;PSMD3;...
Mitophagy -1.86 8.42e-3 56/68 (82.35%) SQSTM1;MAPK10;BECN1;...
Basal transcription factors -1.87 9.82e-3 37/45 (82.22%) TAF12;CCNH;TAF11;...
Metabolism of xenobiotics by cytochrome P450 -1.89 9.82e-3 49/77 (63.64%) ALDH3B1;UGT2B15;ADH1A;...
Huntington disease -1.94 1.23e-2 233/306 (76.14%) CASP8;PSMB6;NDUFA9;...
Proteasome -1.99 6.55e-3 44/46 (95.65%) PSMB6;PSMD3;PSMC2;...
Mineral absorption -2.13 0.00e+0 48/60 (80%) ATP2B1;MT2A;VDR;...
Oxidative phosphorylation -2.21 0.00e+0 93/133 (69.92%) ATP6V1C1;ATP6V0C;NDUFA9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H