Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4N6EK)

Drug Name
LY293558 Drug Info
Synonyms
Tezampanel; 154652-83-2; LY-293558; LY293558; Ted-isoquinoline-3-cooh; LY 293558; UNII-GA36S2O9C2; CHEMBL14935; GA36S2O9C2; 150131-78-5; Decahydro-6-(2-(1H-tetrazol-5-yl)ethyl)-3-isoquinolinecarboxylic acid; 6-(2-(1H-Tetrazol-5-yl)ethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid; 3-Isoquinolinecarboxylic acid, decahydro-6-(2-(1H-tetrazol-5-yl)ethyl)-, (3S,4aR,6R,8aR)-; 3-Isoquinolinecarboxylic acid, decahydro-6-(2-(1H-tetrazol-5-yl)ethyl)-, (3S-(3alpha,4aalpha,6beta,8aalpha))-; Tezampanel [INN]
Therapeutic ClassAnalgesics
Cross-matching ID
PubChem CID
127894
ChEBI ID
CHEMBL14935
CAS Number
CAS 154652-83-2
TTD Drug ID
D0B0NQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.11 0.00e+0 44/46 (95.65%) PSMA6;PSMA4;PSMA2;...
Th1 and Th2 cell differentiation -1.63 4.52e-2 80/92 (86.96%) ZAP70;MAPK3;CD3E;...
IL-17 signaling pathway -1.63 4.64e-2 84/94 (89.36%) IL17RA;CEBPB;TRAF4;...
Gastric acid secretion -1.65 4.13e-2 63/76 (82.89%) ADCY1;ADCY3;SLC9A1;...
Tyrosine metabolism -1.65 4.25e-2 30/36 (83.33%) ADH7;DBH;COMT;...
Inositol phosphate metabolism -1.66 3.62e-2 66/73 (90.41%) PIKFYVE;ISYNA1;MTMR4;...
Melanogenesis -1.68 3.28e-2 74/101 (73.27%) FZD6;PLCB2;DVL2;...
Phenylalanine metabolism -1.68 3.32e-2 14/17 (82.35%) PAH;HPD;AOC3;...
Phosphatidylinositol signaling system -1.69 3.42e-2 82/97 (84.54%) MTMR4;PIP4K2A;PIK3C3;...
Tryptophan metabolism -1.69 3.34e-2 35/42 (83.33%) IDO1;ALDH8A1;ALDH3A2;...
Glyoxylate and dicarboxylate metabolism -1.70 3.18e-2 23/30 (76.67%) PCCA;GLUL;AMT;...
Glycolysis / Gluconeogenesis -1.70 3.29e-2 56/67 (83.58%) ALDH3A2;ALDOC;PCK1;...
Choline metabolism in cancer -1.72 2.95e-2 84/98 (85.71%) AKT1;SLC22A2;PLPP2;...
Amoebiasis -1.73 2.99e-2 99/102 (97.06%) SERPINB4;ARG1;PLCB2;...
NF-kappa B signaling pathway -1.73 3.02e-2 90/104 (86.54%) CD40LG;BCL2L1;ZAP70;...
Apelin signaling pathway -1.74 3.25e-2 117/137 (85.4%) PIK3C3;PLIN1;SPHK2;...
beta-Alanine metabolism -1.78 2.07e-2 25/30 (83.33%) HIBCH;AOC3;ALDH3B1;...
Aldosterone-regulated sodium reabsorption -1.79 1.92e-2 34/37 (91.89%) HSD11B2;MAPK3;PDPK1;...
GnRH secretion -1.79 2.12e-2 60/64 (93.75%) AKT1;PLCB2;PLCB4;...
Cholinergic synapse -1.81 1.94e-2 99/113 (87.61%) AKT1;PLCB2;GNG7;...
VEGF signaling pathway -1.83 1.56e-2 50/59 (84.75%) MAPK3;CASP9;SPHK2;...
Neutrophil extracellular trap formation -1.84 1.78e-2 101/189 (53.44%) AKT1;PLCB2;CYBA;...
Mineral absorption -1.84 2.07e-2 48/60 (80%) ATOX1;ATP2B1;SLC26A6;...
Chemokine signaling pathway -1.89 1.49e-2 163/192 (84.9%) AKT1;PTK2B;PLCB2;...
Renin secretion -1.98 6.22e-3 61/69 (88.41%) EDN3;CTSB;PLCB2;...
Fructose and mannose metabolism -1.99 8.29e-3 30/33 (90.91%) ALDOC;SORD;PFKFB3;...
Pentose phosphate pathway -2.03 6.22e-3 25/30 (83.33%) H6PD;PGD;PGLS;...
Carbohydrate digestion and absorption -2.04 1.24e-2 37/47 (78.72%) AKT1;PLCB2;ATP1B3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H