Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4PRFC)

• Drug Name: Bupivacaine Drug Info
• Synonyms: Anekain; Bloqueina; Bucaine; Bupivacaina; Bupivacainum; Bupivan; CBupivacaine; Carbostesin; DepoBupivacaine; Marcaina; Marcaine; Sensorcaine; Bupivacaine Carbonate; Bupivacaine HCL; Bupivacaine HCL KIT; Marcaine HCL; Marcaine Spinal; AH 250; Win 11318; Win 11318 HCl; Bucaine (TN); Bupivacaina [INN-Spanish]; Bupivacaine (INN); Bupivacaine Monohydrochloride, Monohydrate; Bupivacaine [INN:BAN]; Bupivacainum [INN-Latin]; DL-Bupivacaine; DUR-843; Marcain (TN); Marcaine (TN); Sensorcaine (TN); Sensorcaine-MPF; Sensorcaine-MPFSpinal; Transdur-Bupivacaine; Vivacaine (TN); Dl-1-Butyl-2',6'-pipecoloxylidide; (1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide; (inverted exclamation markA)-bupivacaine; 1-Butyl-2',6'-pipecoloxylidide; 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide; 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
• Therapeutic Class: Anesthetics
• Cross-matching ID:
  PubChem CID: 2474
  ChEBI ID: CHEMBL1098
  CAS Number: CAS 38396-39-3
  TTD Drug ID: D0A0FL
  INTEDE Drug ID: DR0243

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proximal tubule bicarbonate reclamation	2.34	0.00e+0	21/23 (91.3%)	SLC4A4;GLUD2;ATP1B3;...
Pentose phosphate pathway	2.04	0.00e+0	25/30 (83.33%)	PFKL;PFKP;ALDOC;...
beta-Alanine metabolism	2.02	0.00e+0	25/30 (83.33%)	ALDH6A1;ALDH3A1;ABAT;...
Glycolysis / Gluconeogenesis	1.87	1.71e-2	56/67 (83.58%)	PFKL;PFKP;ALDH3A1;...
Gastric acid secretion	1.83	3.83e-2	63/76 (82.89%)	SST;KCNJ16;GNAQ;...
Circadian entrainment	1.78	4.33e-2	85/97 (87.63%)	GNAQ;PRKCA;GNG11;...
ECM-receptor interaction	-1.61	4.86e-2	80/88 (90.91%)	COL1A1;COL4A5;SDC1;...
Amoebiasis	-1.64	4.68e-2	99/102 (97.06%)	CTSG;TNF;COL1A1;...
Non-alcoholic fatty liver disease	-1.65	4.60e-2	126/155 (81.29%)	CYCS;CASP8;AKT1;...
Malaria	-1.73	1.84e-2	44/50 (88%)	TNF;SDC1;ACKR1;...
Rheumatoid arthritis	-1.77	1.76e-2	78/93 (83.87%)	HLA-DOB;TNF;ATP6V0E1;...
Regulation of lipolysis in adipocytes	-1.88	4.38e-3	52/55 (94.55%)	NPY1R;MGLL;ADCY9;...
IL-17 signaling pathway	-1.90	1.02e-3	84/94 (89.36%)	CASP8;ANAPC5;NFKBIA;...
Systemic lupus erythematosus	-1.91	1.23e-3	45/135 (33.33%)	HLA-DOB;CTSG;RO60;...
Legionellosis	-1.91	1.53e-3	51/57 (89.47%)	HSPA1A;SAR1B;PYCARD;...
Pertussis	-2.15	0.00e+0	64/76 (84.21%)	IL1B;IRF3;CALML5;...
Staphylococcus aureus infection	-2.21	0.00e+0	72/95 (75.79%)	KRT33A;FGG;CFI;...
Complement and coagulation cascades	-2.23	0.00e+0	76/85 (89.41%)	A2M;C7;CFHR2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.03uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼