Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4PUDW)

Drug Name
L-Glutamic Acid Drug Info
Synonyms
Aciglut; Glu; Glusate; Glut; Glutacid; Glutamicol; Glutamidex; Glutaminol; Glutaton; Gulutamine; Acide glutamique; Acido glutamico; Acidum glutamicum; Acidum glutaminicum; Glutamic acid polymer; Glutaminic acid; E 620; A-Aminoglutaric acid; A-Glutamic acid; Acide glutamique [INN-French]; Acido glutamico [INN-Spanish]; Acidum glutamicum [INN-Latin]; D-Glutamiensuur; Glutamic Acid [USAN:INN]; Glutamic acid (VAN); Glutaminic acid (VAN); Gulutamine (USP); L-Glutamic acid hydrochloride; L-Glutaminic acid; L-Glutaminsaeure; L-glu; L-glutamate; Alpha-Aminoglutaric acid (VAN); Alpha-L-Glutamic acid polymer; Glutamic Acid (L-glutamic acid); Glutamic acid (H-3); H-Glu-OH; L-2-Aminoglutaric acid; L-Glutamic acid (9CI); L-Glutamic acid (JAN); L-Glutamic acid, homopolymer; L-a-Aminoglutaric acid; L-alpha-Aminoglutaric acid; Poly-L-glutamate; Sodium Glutamate (L-glutamic Acid); Glutamic acid, L-, peptides; L-Glutamic acid, homopolymer (9CI); Poly(alpha-L-glutamic acid); Glutamic acid, L-(7CI,8CI); L-(+)-glutamic acid; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioic acid; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylic acid
Therapeutic ClassDietary supplement
Cross-matching ID
PubChem CID
33032
ChEBI ID
CHEMBL575060
CAS Number
CAS 56-86-0
TTD Drug ID
D00ENY
VARIDT Drug ID
DR00005

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Riboflavin metabolism 1.88 3.61e-2 7/8 (87.5%) ENPP1;FLAD1;ACP5;...
Ether lipid metabolism 1.86 2.25e-2 32/49 (65.31%) PLA2G2A;ENPP2;PLD3;...
Pertussis -1.67 4.40e-2 64/76 (84.21%) ITGB1;IL1A;MAPK1;...
Ferroptosis -1.67 4.60e-2 36/41 (87.8%) ACSL5;SLC3A2;SLC7A11;...
Valine, leucine and isoleucine degradation -1.68 4.21e-2 42/48 (87.5%) ACADSB;AUH;MCCC1;...
Coronavirus disease -1.70 3.26e-2 215/232 (92.67%) RPL3L;C1QA;RPL11;...
Renin secretion -1.73 2.71e-2 61/69 (88.41%) PLCB3;CALML4;PTGER2;...
Gastric acid secretion -1.73 2.84e-2 63/76 (82.89%) PLCB3;CALML4;ADCY9;...
Fatty acid degradation -1.76 2.26e-2 40/43 (93.02%) ADH1A;ACSL5;HADHA;...
Pentose and glucuronate interconversions -1.76 2.47e-2 17/34 (50%) UGP2;CRYL1;UGDH;...
Retinol metabolism -1.77 2.39e-2 41/68 (60.29%) CYP3A4;CYP2C9;ADH1A;...
Mineral absorption -1.79 2.05e-2 48/60 (80%) HMOX1;MT1G;MT1X;...
Glycine, serine and threonine metabolism -1.82 1.76e-2 31/40 (77.5%) MAOA;SHMT1;BPGM;...
Tryptophan metabolism -1.84 1.40e-2 35/42 (83.33%) CAT;ALDH8A1;AOC1;...
Metabolism of xenobiotics by cytochrome P450 -1.85 1.27e-2 49/77 (63.64%) CYP3A4;CYP2C9;ADH1A;...
Drug metabolism -1.88 8.68e-3 78/151 (51.66%) TPMT;FMO4;FMO5;...
Ascorbate and aldarate metabolism -1.91 1.09e-2 15/30 (50%) RGN;UGDH;UGT2A3;...
Complement and coagulation cascades -1.96 7.24e-3 76/85 (89.41%) C4BPA;A2M;F2R;...
Nitrogen metabolism -1.98 0.00e+0 16/17 (94.12%) CPS1;CA5A;CA9;...
Porphyrin and chlorophyll metabolism -2.06 0.00e+0 23/43 (53.49%) UGT2A3;UGT2B17;UGT2B15;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H