Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4PXF6)

Drug Name
Desoximetasone Drug Info
Synonyms
Desoximetasona; Desoximetasonum; Topicort; HOE-304; R-2113; Topicort (TN); Topicort Emollient (TN); A-41-304; Desoximetasone (USP/INN); (11beta,16alpha)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one; 9-Fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; 9alpha-fluoro-16alpha-methyl-Delta(1)-corticosterone
Therapeutic ClassAntiinflammatory Agents
Cross-matching ID
PubChem CID
5311067
ChEBI ID
CHEMBL1766
CAS Number
CAS 140218-14-0
TTD Drug ID
D0CZ1Q
ACDINA Drug ID
D00998

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.14 0.00e+0 93/133 (69.92%) COX17;NDUFA1;COX6B1;...
mRNA surveillance pathway 2.00 3.61e-3 71/98 (72.45%) NXT2;PAPOLG;HBS1L;...
Proteasome 1.97 4.82e-3 44/46 (95.65%) PSMD2;PSME3;PSMC4;...
Spliceosome 1.87 1.63e-2 101/150 (67.33%) LSM5;PUF60;SNRPG;...
Bile secretion 1.85 1.59e-2 68/90 (75.56%) AQP1;CA2;KCNN2;...
Aldosterone-regulated sodium reabsorption 1.78 2.65e-2 34/37 (91.89%) SGK1;SCNN1A;ATP1B3;...
Proximal tubule bicarbonate reclamation 1.72 4.13e-2 21/23 (91.3%) AQP1;CA2;ATP1B3;...
IL-17 signaling pathway -1.84 3.79e-2 84/94 (89.36%) ANAPC5;HSP90AB1;CXCL5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H